| DB ID | MyCo_5881 |
| Title | Positive fungal quantitative PCR and Th17 cytokine detection in bronchoalveolar lavage fluids: Complementary biomarkers of hypersensitivity pneumonitis? |
| Year | 2016 |
| PMID | 27098083 |
| Fungal Diseases involved | Hypersensitivity pneumonitis |
| Associated Medical Condition | None |
| Genus | Wallemia |
| Species | sebi |
| Organism | Wallemia sebi |
| Ethical Statement | This study was approved by the ethics com- mittee of Besançon University Hospital. |
| Site of Infection | None |
| Opportunistic invasive | None |
| Sample type | Body fluid |
| Sample source | Bronchoalveolar lavage fluid (BALF) |
| Host Group | Human |
| Host Common name | Human |
| Host Scientific name | Homo sapiens |
| Biomarker Name | IL-6 |
| Biomarker Full Name | Interleukin-6 |
| Biomarker Type | Diagnostic |
| Biomolecule | Protein |
| Geographical Location | France |
| Cohort | Over a two-year period, all patients undergoing bronchoalveolar lavage for the diagnosis of ILD were asked to provide a residual amount of 2 ml of BALF for the study. We analyzed 39 BALF samples from 12 ILD patients with sarcoidosis, 11 with IPF and 16 with HP. We determined the levels of 10 cytokines and carried out quantitative PCR for 10 microorganisms involved in farm-associated or domestic forms of HP. |
| Cohort No. | 16 |
| Age Group | 58.7 |
| P Value | p< 0.05 |
| Sensitivity | None |
| Specificity | None |
| Positive Predictive Value | None |
| MIC | None |
| Fold Change | None |
| Pathway | None |
| Disease Introduction Mechanism | Interstitial lung disease (ILD) is a large group of diseases that in- cludes hypersensitivity pneumonitis (HP), idiopathic pulmonary fibro-sis (IPF) and sarcoidosis. It is often difficult to distinguish between ILDs, due to their nonspecific clinical and functional signs (Jeong et al., 2014).However, accurate diagnosis is important because the various ILDs have different prognoses and require specific management. |
| Technique | PCR |
| Analysis Method | qRT-PCR |
| ELISA kits | None |
| Assay Data | None |
| Validation Techniques used | qRT-PCR |
| Up Regulation Down Regulation | Increase |
| Sequence Data | None |
| External Link | None |
