| DB ID | MyCo_5799 |
| Title | Interplay of interferon-gamma and macrophage polarization during Talaromyces marneffei infection |
| Year | 2019 |
| PMID | 31199985 |
| Fungal Diseases involved | Talaromycosis |
| Associated Medical Condition | None |
| Genus | Talaromyces |
| Species | marneffei |
| Organism | Talaromyces marneffei |
| Ethical Statement | The experiments were approved by the Medical Ethics committee of Sun Yat-sen Memorial Hospital, Sun Yat-sen University Rapid review of clinical research. |
| Site of Infection | None |
| Opportunistic invasive | None |
| Sample type | None |
| Sample source | None |
| Host Group | Human |
| Host Common name | Human |
| Host Scientific name | Homo sapiens |
| Biomarker Name | IFN-γ |
| Biomarker Full Name | Interferon gamma |
| Biomarker Type | Diagnostic |
| Biomolecule | Protein |
| Geographical Location | USA |
| Cohort | None |
| Cohort No. | None |
| Age Group | None |
| P Value | None |
| Sensitivity | None |
| Specificity | None |
| Positive Predictive Value | None |
| MIC | None |
| Fold Change | None |
| Pathway | None |
| Disease Introduction Mechanism | Talaromyces marneffei (T. marneffei, formerly Penicillium marneffei), a pathogenic dimorphic fungus, causes signi cant mortality in Thailand, Vietnam, Hong Kong, Southern China, Taiwan, India, and Laos. In these areas, T. marneffei infection occurs particularly in patients infected with the human immunode ciency virus (HIV) (82.7% of pa- tients). This fungal disease ranks third among systemic opportu- nistic infections in AIDS patients. The pathogenesis of T. marneffei in mammals is not yet fully understood. The infection commonly occurs through the inhalation of aerosolized conidia from the environment that subsequently colonize the respiratory tract. This organism is able to undergo a morphological transition that is coordinated with environmental changes. Typically, T. marneffei grows as a mycelial form in the environment but multiplies rapidly as a yeast form in the host and within macrophages. |
| Technique | PCR |
| Analysis Method | qRT-PCR |
| ELISA kits | None |
| Assay Data | None |
| Validation Techniques used | qRT-PCR, Flow Cytometry Analysis |
| Up Regulation Down Regulation | Positive |
| Sequence Data | GenBank accession: KR902349 |
| External Link | None |
