| DB ID | MyCo_5775 |
| Title | Anti-CD3 antibody decreases inflammation and improves outcome in a murine model of Pneumocystis pneumonia |
| Year | 2010 |
| PMID | 19949093 |
| Fungal Diseases involved | Pneumocystis pneumonia |
| Associated Medical Condition | None |
| Genus | Pneumocystis |
| Species | spp. |
| Organism | Pneumocystis spp. |
| Ethical Statement | None |
| Site of Infection | None |
| Opportunistic invasive | None |
| Sample type | Biopsy |
| Sample source | Extracted Lungs Tissue |
| Host Group | Animal |
| Host Common name | Mice |
| Host Scientific name | Mus musculus |
| Biomarker Name | Anti-CD3 antibody-OKT3 |
| Biomarker Full Name | Anti-CD3 antibody-OKT3 |
| Biomarker Type | Diagnostic |
| Biomolecule | Protein |
| Geographical Location | USA |
| Cohort | Mice were infected by intranasal inoculation with 1 × 105 Pc cysts. Four weeks later, Pc- infected SCID mice were immune reconstituted with 5 × 107 splenocytes from syngeneic donor strains to mimic IRIS as previously described (4,8). Anti-CD3 F(ab′)2 treatment was begun when the mice were clearly symptomatic, which we defined as either the average body weight loss of more than 10% or average respiratory rate was more than 400 respirations per minute. |
| Cohort No. | None |
| Age Group | None |
| P Value | None |
| Sensitivity | None |
| Specificity | None |
| Positive Predictive Value | None |
| MIC | None |
| Fold Change | None |
| Pathway | None |
| Disease Introduction Mechanism | None |
| Technique | PCR |
| Analysis Method | qRT-PCR |
| ELISA kits | None |
| Assay Data | None |
| Validation Techniques used | qRT-PCR |
| Up Regulation Down Regulation | Positive |
| Sequence Data | None |
| External Link | None |
