| DB ID | MyCo_5771 |
| Title | Serum (1,3)-Beta-d-Glucan has suboptimal performance for the diagnosis of Pneumocystis jirovecii pneumonia in cancer patients and correlates poorly with respiratory burden as measured by quantitative PCR |
| Year | 2020 |
| PMID | 32650108 |
| Fungal Diseases involved | Pneumocystis jirovecii pneumonia |
| Associated Medical Condition | Cancer patients |
| Genus | Pneumocystis |
| Species | jirovecii |
| Organism | Pneumocystis jirovecii |
| Ethical Statement | This retrospective study was conducted at The University of Texas MD Anderson Cancer Center, Houston, Texas, after approval by the institutional review board. |
| Site of Infection | None |
| Opportunistic invasive | None |
| Sample type | Body fluid |
| Sample source | Serum |
| Host Group | Human |
| Host Common name | Human |
| Host Scientific name | Homo sapiens |
| Biomarker Name | BDG |
| Biomarker Full Name | 1-3-beta-D-Glucan |
| Biomarker Type | Diagnostic |
| Biomolecule | Protein |
| Geographical Location | USA |
| Cohort | This retrospective study was conducted at The University of Texas MD Anderson Cancer Center, Houston, Texas, after approval by the institutional review board. The study population included non-HIV/AIDS patients who had a qPCR assay performed on respi- ratory specimens obtained through BAL or bronchial washing (BW) as part of a diagnostic work up for pulmonary infiltrates of un- known etiology. We identified 101 PCP patients (73 definite/probable, 28 possible) and 74 controls. |
| Cohort No. | 101 |
| Age Group | None |
| P Value | None |
| Sensitivity | None |
| Specificity | None |
| Positive Predictive Value | None |
| MIC | None |
| Fold Change | None |
| Pathway | None |
| Disease Introduction Mechanism | Pneumocystis jirovecii is an opportunistic fungal pathogen that causes Pneumocystis pneumonia (PCP) in immunocompromised hosts. As Pneumocystis cannot be grown in culture, microscopic staining in sputum and bronchoalveolar lavage (BAL) samples has been the diagnostic gold standard for several decades. Use of fluorescence microscopy and monoclonal antibodies have significantly increased the diagnostic yield in patients with AIDS. |
| Technique | PCR |
| Analysis Method | qRT-PCR |
| ELISA kits | None |
| Assay Data | None |
| Validation Techniques used | qRT-PCR |
| Up Regulation Down Regulation | Negative |
| Sequence Data | None |
| External Link | None |
