| DB ID | MyCo_5730 |
| Title | MyD88 and TLR2, but not TLR4, are required for host defense against Cryptococcus neoformans |
| Year | 2005 |
| PMID | 15714580 |
| Fungal Diseases involved | Cryptococcus neoformans infection |
| Associated Medical Condition | None |
| Genus | Cryptococcus |
| Species | neoformans |
| Organism | Cryptococcus neoformans |
| Ethical Statement | All in vivo studies were performed in agreement with the European Union guidelines of animal care and were approved by the relevant national committees. |
| Site of Infection | None |
| Opportunistic invasive | None |
| Sample type | Biopsy |
| Sample source | Homogenized tissue extracts |
| Host Group | Animal |
| Host Common name | Mice |
| Host Scientific name | Mus musculus |
| Biomarker Name | TLR4 |
| Biomarker Full Name | Toll-like receptor 4 |
| Biomarker Type | Negative |
| Biomolecule | Protein |
| Geographical Location | Italy |
| Cohort | MyD88–/– and TLR2–/– mice, derived and backcrossed for five generations with C57BL/6, were obtained from Dr. Shizuo Akira (Osaka University, Japan) through Dr. Douglas Golenbock (University of Massachusetts, MA). Control WT C57BL/6 mice were purchased from Charles River Italia (Calco, Lecco, Italy). C3H/HeJ LPS-hyporesponsive mice, which have a loss of function mutation in TLR4, and control C3H/HeN mice, were also purchased from Charles River. |
| Cohort No. | None |
| Age Group | None |
| P Value | None |
| Sensitivity | None |
| Specificity | None |
| Positive Predictive Value | None |
| MIC | None |
| Fold Change | None |
| Pathway | None |
| Disease Introduction Mechanism | None |
| Technique | PCR |
| Analysis Method | qRT-PCR |
| ELISA kits | None |
| Assay Data | None |
| Validation Techniques used | qRT-PCR |
| Up Regulation Down Regulation | Negative |
| Sequence Data | None |
| External Link | None |
