| DB ID | MyCo_5706 |
| Title | Inflammatory and Anti-inflammatory Responses Co-exist Inside Lung Granuloma of Fatal Cases of Coccidioidomycosis: A Pilot Report |
| Year | 2018 |
| PMID | 29736739 |
| Fungal Diseases involved | Coccidioidomycosis |
| Associated Medical Condition | None |
| Genus | Coccidioides |
| Species | spp. |
| Organism | Coccidioides spp. |
| Ethical Statement | This study wa approved by the Bioethics Committee of the Faculty of Medicine at the Universidad Auto ´noma de Nuevo Leon (UANL) No. IN10-004. |
| Site of Infection | None |
| Opportunistic invasive | Opportunistic |
| Sample type | Biopsy |
| Sample source | Extracted lungs tissue |
| Host Group | Human |
| Host Common name | Human |
| Host Scientific name | Homo sapiens |
| Biomarker Name | CD206 |
| Biomarker Full Name | CD206 |
| Biomarker Type | Diagnostic |
| Biomolecule | Protein |
| Geographical Location | Mexico |
| Cohort | A retrospective study was conducted on lung tissues from six fatal cases of confirmed pneumonia by Coccidioides spp. identified in culture or by histopathological findings. Six fatal cases of Coccidioides spp. pneumonia were included in this study; the median age of patients was 47.6 + 20.6 years. |
| Cohort No. | 6 |
| Age Group | 47.6 + 20.6 |
| P Value | p<0.05 |
| Sensitivity | None |
| Specificity | None |
| Positive Predictive Value | None |
| MIC | None |
| Fold Change | None |
| Pathway | None |
| Disease Introduction Mechanism | Coccidioidomycosis is a fungal disease caused by Coccidioides immitis or Coccidioides posadasii; these microorganisms are considered both as primary and opportunistic pathogens. Endemic zones are located in the southern USA (California, Arizona, Texas, Nevada, Utah) and northern Mexico (Baja California, Sonora, Chihuahua, Coahuila, Nuevo Leo ´n, Tamauli- pas). Coccidioides spp. is a soil-dwelling agent, and the infection is typically acquired by inhalation of spores during its saprophyte phase. Infection is usually asymptomatic or sub-clinical in previously healthy people. A number of 150,000 new infections per year are estimated. It is expected that 40% of individuals exposed to this fungus in endemic regions develop a symptomatic disease. Severe forms of coccidioidomycosis are mainly found in immunocompromised patients, such as pregnant women, diabetics, patients receiving immunosuppressant therapy and people infected with HIV. |
| Technique | PCR |
| Analysis Method | qRT-PCR |
| ELISA kits | None |
| Assay Data | None |
| Validation Techniques used | qRT-PCR |
| Up Regulation Down Regulation | Increase |
| Sequence Data | None |
| External Link | None |