| DB ID | MyCo_5701 |
| Title | Differential Expression of Local Immune Response Genes in the Vagina: Implication for the Diagnosis of Vaginal Infections |
| Year | 2020 |
| PMID | 32246370 |
| Fungal Diseases involved | Vulvovaginal candidiasis |
| Associated Medical Condition | None |
| Genus | Candida |
| Species | albicans |
| Organism | Candida albicans |
| Ethical Statement | The study was approved by the Ethical Committee of the D.O. Ott Research Institute of Ob- stetrics, Gynecology, and Reproductology (protocol No. 78/2016). |
| Site of Infection | Vagina |
| Opportunistic invasive | Opportunistic |
| Sample type | Body fluid |
| Sample source | Vaginal Fluid |
| Host Group | Human |
| Host Common name | Human |
| Host Scientific name | Homo sapiens |
| Biomarker Name | TLR4 |
| Biomarker Full Name | TLR4 |
| Biomarker Type | Diagnostic |
| Biomolecule | Gene |
| Geographical Location | St. Peters- burg |
| Cohort | The study participants were women of reproductive age examined in a gynecological clinic in St. Peters- burg in March 2017 to November 2018. The main complaints were vulvovaginal symptoms. During examination, the following vulvovaginal signs and symptoms were revealed: abnormal vaginal discharge, vulval soreness/itching and erythema, malodor, dysuria, dyspareunia, purulent or mucopurulent endocervical exudate, cervical petechiae, and abdominal pain. |
| Cohort No. | None |
| Age Group | None |
| P Value | p<0.001 |
| Sensitivity | None |
| Specificity | None |
| Positive Predictive Value | None |
| MIC | None |
| Fold Change | None |
| Pathway | None |
| Disease Introduction Mechanism | Inflammatory and non-inflammatory vaginal infections, in particular bacterial vaginosis (BV), aerobic vaginitis (AV), and vulvovaginal candidosis (VVC) caused by opportunistic microorganisms are very com- mon in premenopausal women and account for most cases of vaginal discharge. Along with psychosexual problems, these infections can lead to gyne- cological and obstetrical complications VVC manifested as curdy-white discharge, vulval and vaginal soreness/ itching, and erythema and in ~90% women is caused by excessive growth of Candida albicans (remaining cases are caused by other species of yeast-like fungi, e.g. Candida glabrata). |
| Technique | PCR |
| Analysis Method | qRT-PCR |
| ELISA kits | None |
| Assay Data | None |
| Validation Techniques used | qRT-PCR, Transcriptional Profiling |
| Up Regulation Down Regulation | Positive |
| Sequence Data | None |
| External Link | None |
