| DB ID | MyCo_5694 |
| Title | ROS-induced Oxidative Injury involved in Pathogenesis of Fungal Keratitis via p38 MAPK Activation |
| Year | 2017 |
| PMID | 28874754 |
| Fungal Diseases involved | Fungal keratitis |
| Associated Medical Condition | None |
| Genus | Candida |
| Species | albicans |
| Organism | Candida albicans |
| Ethical Statement | Experimental animals were treated in accordance with the ARVO Statement for the Use of Animals in Ophthalmic and Vision Research, and the protocols were approved by the Tianjin Medical University Institutional Animal Care and Use Committee. |
| Site of Infection | None |
| Opportunistic invasive | None |
| Sample type | Biopsy |
| Sample source | Extracted RNA |
| Host Group | Animal |
| Host Common name | Mice |
| Host Scientific name | Mus musculus |
| Biomarker Name | MAPK |
| Biomarker Full Name | p38 mitogen-activated protein kinases |
| Biomarker Type | Diagnostic |
| Biomolecule | Protein |
| Geographical Location | China |
| Cohort | None |
| Cohort No. | None |
| Age Group | None |
| P Value | None |
| Sensitivity | None |
| Specificity | None |
| Positive Predictive Value | None |
| MIC | None |
| Fold Change | None |
| Pathway | None |
| Disease Introduction Mechanism | Fungal keratitis is one of the leading causes of corneal blindness in developing countries, and its incidence is increasing in highly populous countries in Asia and Africa can cause systemic mycosis, opportunistic mucosal candidiasis, endogenous endophthalmitis, and suppurative keratitis . C. albicans specifically overcomes the ocular surface defense and penetrates the corneal stroma after converting into a filamentous form. Hyphal invasion then induces host responses that may cause corneal inflam- mation and ulceration, which in turn participates in the pathophysiology of fungal keratitis. |
| Technique | PCR |
| Analysis Method | qRT-PCR |
| ELISA kits | None |
| Assay Data | None |
| Validation Techniques used | qRT-PCR, Western blot analysis |
| Up Regulation Down Regulation | Increase |
| Sequence Data | None |
| External Link | None |
