| DB ID | MyCo_5682 |
| Title | IL-1β-MyD88-mTOR Axis Promotes Immune-Protective IL-17A+Foxp3+ Cells During Mucosal Infection and Is Dysregulated With Aging |
| Year | 2020 |
| PMID | 33240286 |
| Fungal Diseases involved | Oral Candida albicans infection |
| Associated Medical Condition | None |
| Genus | Candida |
| Species | albicans |
| Organism | Candida albicans |
| Ethical Statement | The studies involving human participants were reviewed and approved by IRB, University Hospitals, CWRU. The patients/ participants provided their written informed consent to participate in this study. The animal study was reviewed and approved by IACUC. |
| Site of Infection | Mouth |
| Opportunistic invasive | None |
| Sample type | Biopsy |
| Sample source | Extracted RNA |
| Host Group | Animal |
| Host Common name | Mice |
| Host Scientific name | Mus musculus |
| Biomarker Name | IL-1b/MyD88/Treg |
| Biomarker Full Name | IL-1b/MyD88/Treg |
| Biomarker Type | Diagnostic |
| Biomolecule | Protein |
| Geographical Location | USA |
| Cohort | Young (6-9 weeks of age) Myd88flox/flox, Foxp3-YFPcre transgenic mice, BALB/cJ, C57BL/6J, Foxp3GFP reporter, CD45.1 congenic mice, and IL-1R-/- mice, as well as aged (12–18 months of age) C57BL/6 mice were purchased from Jackson Laboratories. Animals of both genders were used for experiments. |
| Cohort No. | None |
| Age Group | None |
| P Value | None |
| Sensitivity | None |
| Specificity | None |
| Positive Predictive Value | None |
| MIC | None |
| Fold Change | None |
| Pathway | None |
| Disease Introduction Mechanism | None |
| Technique | PCR |
| Analysis Method | qRT-PCR |
| ELISA kits | None |
| Assay Data | None |
| Validation Techniques used | qRT-PCR, Flow Cytometry |
| Up Regulation Down Regulation | Positive |
| Sequence Data | None |
| External Link | None |
