| DB ID | MyCo_5663 |
| Title | Hyphal Als proteins act as CR3 ligands to promote immune responses against Candida albicans |
| Year | 2024 |
| PMID | 38724513 |
| Fungal Diseases involved | Invasive candidiasis |
| Associated Medical Condition | None |
| Genus | Candida |
| Species | albicans |
| Organism | Candida albicans |
| Ethical Statement | All studies described have been approved by UC Irvine oversight committees, including the use of mice as a source of macrophages and dendritic cells by the UC Irvine IACUC. The mouse systemic infection studies were approved by the Institutional Animal Care and Use Committee at the Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center. |
| Site of Infection | None |
| Opportunistic invasive | Invasive |
| Sample type | Biopsy |
| Sample source | Extracted tissue |
| Host Group | Animal |
| Host Common name | Mice |
| Host Scientific name | Mus musculus |
| Biomarker Name | Als3 |
| Biomarker Full Name | Als3 |
| Biomarker Type | Diagnostic |
| Biomolecule | Protein |
| Geographical Location | USA |
| Cohort | CD18−/− mice were originally provided by Claire Doerschuk (University of North Carolina, Chapel Hill, NC, USA). Dectin-2-de cient mice were a kind gift from Yoichiro Iwakura (University of Tokyo, Tokyo, Japan). Age- and sex-matched C57BL/6 J mice were purchased from Jackson Laboratories (Bar Harbor, ME, USA). 6-week-old male and female C57BL/6 J mice were purchased for in vivo experiments. |
| Cohort No. | None |
| Age Group | None |
| P Value | None |
| Sensitivity | None |
| Specificity | None |
| Positive Predictive Value | None |
| MIC | None |
| Fold Change | None |
| Pathway | None |
| Disease Introduction Mechanism | Invasive candidiasis, caused mainly by the opportunistic fungus Candida albicans, is a leading cause of nosocomial bloodstream infection in developed countries, with a mortality that can exceed 40% despite antifungal treatment1. The limited ef cacy of antifungal drugs and the rising incidence of antifungal resistance indicate a need to develop new therapies for invasive candidiasis1. Opportunistic“high-damaging” C. albicans strains produce toxic factors, such as pore-forming candidalysin, aspartyl proteases (Saps), and the agglutinin-like sequence (Als) proteins, during the transition from benign commensal yeasts to pathogenic hyphae, exacerbating in ammation2–5. Compared to yeasts, hyphae cause more tissue damage, both directly via candida-lysin and Saps and indirectly by exacerbating the in amatory responses. However, the interactions between hyphae and myeloid cells that drive antifungal immunity remain poorly understood. |
| Technique | PCR |
| Analysis Method | qRT-PCR |
| ELISA kits | None |
| Assay Data | None |
| Validation Techniques used | qRT-PCR |
| Up Regulation Down Regulation | Positive |
| Sequence Data | None |
| External Link | None |
