| DB ID | MyCo_5645 |
| Title | Aspergillus Bronchitis in Patients with Cystic Fibrosis |
| Year | 2017 |
| PMID | 28819878 |
| Fungal Diseases involved | Aspergillus bronchitis |
| Associated Medical Condition | Cystic Fibrosis |
| Genus | Aspergillus |
| Species | fumigatus |
| Organism | Aspergillus fumigatus |
| Ethical Statement | Study protocol was approved by the local ethics committee of the Charite ´–Univer- sita ¨tsmedizin Berlin. |
| Site of Infection | None |
| Opportunistic invasive | None |
| Sample type | Body fluid |
| Sample source | Serum |
| Host Group | Human |
| Host Common name | Human |
| Host Scientific name | Homo sapiens |
| Biomarker Name | serum IgG |
| Biomarker Full Name | serum IgG |
| Biomarker Type | Diagnostic |
| Biomolecule | Protein |
| Geographical Location | Germany |
| Cohort | To evaluate the rate of Aspergillus colonization in patients with CF, data were extracted from the German Cystic Fibrosis Registry. Analysis was focused on data collected for 2012 (the German CF registry was revised during the past few years, and data are not available since 2013). Study protocol was approved by the local ethics committee of the Charite ´–Univer- sita ¨tsmedizin Berlin. The study population included all patients with completed datasets concerning Aspergillus and Pseu- domonas infection, forced expiratory volume in one second (FEV1), body mass index (BMI), gender and age. In the German CF registry, colonization by Aspergillus species was defined by the isolation of the fungus from at least one sputum sample per year. |
| Cohort No. | 2599 |
| Age Group | 21 ± 12 |
| P Value | None |
| Sensitivity | None |
| Specificity | None |
| Positive Predictive Value | None |
| MIC | None |
| Fold Change | None |
| Pathway | None |
| Disease Introduction Mechanism | Cystic fibrosis (CF) is a life-limiting autosomal recessive disorder. More than 70,000 individuals worldwide are affected by this multiorgan disease. Abnormally viscous secretions in the lower airways cause obstructions that lead to inflammation, tissue damage and destruction of the lungs. Recurrent pulmonary exacerbations are a predominant feature for many patients with CF. Aspergillus fumigatus is by far the most commonly cultured mold from the sputum of patients with CF with isolation rates varying between 6 and 58%, due to different sampling techniques and sputum processing protocols. |
| Technique | PCR |
| Analysis Method | qRT-PCR |
| ELISA kits | None |
| Assay Data | None |
| Validation Techniques used | qRT-PCR |
| Up Regulation Down Regulation | Positive |
| Sequence Data | None |
| External Link | None |
