| DB ID | MyCo_5626 |
| Title | Genome-Wide Expression Profiling Reveals S100B as Biomarker for Invasive Aspergillosis |
| Year | 2016 |
| PMID | 27047454 |
| Fungal Diseases involved | Invasive aspergillosis |
| Associated Medical Condition | None |
| Genus | Aspergillus |
| Species | fumigatus |
| Organism | Aspergillus fumigatus |
| Ethical Statement | This study was approved by the Ethical Committee of the University Hospital of Wuerzburg (Approval 173/11: Invasive aspergillosis: Biomarkers for prevention, diagnosis and treatment response). |
| Site of Infection | None |
| Opportunistic invasive | Invasive/Opportunistic |
| Sample type | Body fluid |
| Sample source | Blood |
| Host Group | Human |
| Host Common name | Human |
| Host Scientific name | Homo sapiens |
| Biomarker Name | IL1B |
| Biomarker Full Name | Interleukin-1B |
| Biomarker Type | Diagnostic |
| Biomolecule | Protein |
| Geographical Location | Germany |
| Cohort | Blood samples were taken from allogeneic haematopoietic stem cell transplant (alloSCT) recipients and patients receiving myelosuppressive chemotherapy. |
| Cohort No. | None |
| Age Group | 31-70 |
| P Value | p< 0.05 |
| Sensitivity | None |
| Specificity | None |
| Positive Predictive Value | None |
| MIC | None |
| Fold Change | 2 fold |
| Pathway | None |
| Disease Introduction Mechanism | Aspergillus spp. are ubiquitous molds present as saprobes in air, soil, and water. Thus, exposure to their omnipresent spores named conidia occurs constantly and the exposure to the fungus can be considerable. In immunocompromised patients, deposition of conidia on mucous membranes in the lower respiratory tract may result in their germination and subsequent growth into tissue barriers. Leukemia patients, patients after allogeneic stem cell and solid organ transplantation as well as other groups of heavily immunosuppressed patients are at highest risk for Aspergillus infections. |
| Technique | PCR |
| Analysis Method | qRT-PCR |
| ELISA kits | PlateliaTM Aspergillus EIA assay (Bio-Rad, Munich, Germany) |
| Assay Data | None |
| Validation Techniques used | qRT-PCR, GM-Platelia™ Aspergillus Ag ELISA |
| Up Regulation Down Regulation | Down regulated |
| Sequence Data | None |
| External Link | None |
