| DB ID | MyCo_5603 |
| Title | Invasive rhino-orbital-cerebral aspergillosis in an immunocompetent patient |
| Year | 2020 |
| PMID | 32507472 |
| Fungal Diseases involved | Rhino-orbital-aspergillosis |
| Associated Medical Condition | None |
| Genus | Aspergillus |
| Species | spp. |
| Organism | Aspergillus spp. |
| Ethical Statement | None |
| Site of Infection | None |
| Opportunistic invasive | None |
| Sample type | Biopsy |
| Sample source | Extracted tissue |
| Host Group | Human |
| Host Common name | Human |
| Host Scientific name | Homo sapiens |
| Biomarker Name | ITS |
| Biomarker Full Name | Internal Transcribed Spacer |
| Biomarker Type | Diagnostic |
| Biomolecule | Gene |
| Geographical Location | France |
| Cohort | A 61-year-old patient with a history of arterial hypertension, gout and well-controlled diabetes treated by simple diet (last HbA1c: 5.9%) presented in January 2016 with a severe sudden decrease in right visual acuity associated with painless diplopia without exophthalmia, was included in the study. |
| Cohort No. | 1 |
| Age Group | 61 |
| P Value | None |
| Sensitivity | None |
| Specificity | None |
| Positive Predictive Value | None |
| MIC | None |
| Fold Change | None |
| Pathway | None |
| Disease Introduction Mechanism | Rhino-orbital (ROA) or sino-orbital aspergillosis is a disease with a poor prognosis, which is rarely described in immunocompetent patients. Diagnosis of the disease is often delayed due to the absence of specific clinical signs and the anatomically deep localization of the infection. Furthermore, ROA can mimic a neoplastic aetiology or vasculitis resulting in the use of corticoste- roids, which may facilitate progression of the disease. |
| Technique | PCR |
| Analysis Method | qRT-PCR |
| ELISA kits | ELISA Kit- Platelia Aspergillus (Platelia Aspergillus EIA; Bio-Rad Laboratories, Redmond, WA, USA) |
| Assay Data | FDA- Fungitell®, Cape Cod International, Inc.; Falmounth, MA, USA |
| Validation Techniques used | qRT-PCR |
| Up Regulation Down Regulation | Positive |
| Sequence Data | None |
| External Link | None |
