| DB ID | MyCo_5600 |
| Title | Voriconazole resistance genes in Aspergillus flavus clinical isolates |
| Year | 2020 |
| PMID | 32362445 |
| Fungal Diseases involved | Fungal infection |
| Associated Medical Condition | None |
| Genus | Aspergillus |
| Species | flavus |
| Organism | Aspergillus flavus |
| Ethical Statement | Not required |
| Site of Infection | None |
| Opportunistic invasive | None |
| Sample type | Body fluid |
| Sample source | Bronchoalveolar lavage fluid (BALF) |
| Host Group | Human |
| Host Common name | Human |
| Host Scientific name | Homo sapiens |
| Biomarker Name | aldehydereductase XM- 002376518 |
| Biomarker Full Name | aldehydereductase XM- 002376518 |
| Biomarker Type | Diagnostic |
| Biomolecule | Gene |
| Geographical Location | Iran |
| Cohort | This is a comparative experimental study conducted on twenty one A. flavus clinical isolates from various clinical samples including BAL, Sinus (These isolates were identified previously based on morphology on Czapek Yeast Agar and PCR- sequencing of b- tubuline ribosomal DNA gene and were stored in the culture collection of the Medical Mycology Laboratory, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran). One VCZ non- WT A. flavus (no. 498) strains which showed no changes in cyp51A and mdr mRNA expression level in our previous research was included in the present study. |
| Cohort No. | None |
| Age Group | None |
| P Value | p<0.001 |
| Sensitivity | None |
| Specificity | None |
| Positive Predictive Value | None |
| MIC | None |
| Fold Change | 5.6 fold |
| Pathway | None |
| Disease Introduction Mechanism | Aspergillus flavus is known as the most prevalent cause of fungal sinusitis, and fungal keratitis, which is considered as the second most predominant species causing disseminated aspergillosis. It is more often reported from North Africa, South East Asia, and Middle East. Recently, with the increasing number of immunocompromised patients in both pediatric and adult populations the epidemiology of the invasive mycosis is changing and Aspergillus species is reported more than in the past. |
| Technique | PCR |
| Analysis Method | qRT-PCR |
| ELISA kits | None |
| Assay Data | None |
| Validation Techniques used | qRT-PCR |
| Up Regulation Down Regulation | Positive |
| Sequence Data | None |
| External Link | None |
