| DB ID | MyCo_5596 |
| Title | Post-sepsis immunosuppression depends on NKT cell regulation of mTOR/IFN-γ in NK cells |
| Year | 2020 |
| PMID | 32154791 |
| Fungal Diseases involved | Candida infection |
| Associated Medical Condition | Sepsis |
| Genus | None |
| Species | None |
| Organism | None |
| Ethical Statement | The Brigham and Women’s Hospital IACUC approved our mouse studies in accordance with the NIH Guide for the Care and Use of Laboratory Animals (National Academies Press, 2011) and our institution’s American Association for Laboratory Animal Sci- ence certification. All human studies were approved by the Partners Healthcare Institutional Review Board (Boston, Massachusetts, USA). For human studies, informed consent was received from participants or legal surrogates before inclusion in the study. |
| Site of Infection | None |
| Opportunistic invasive | None |
| Sample type | Body fluid |
| Sample source | Plasma |
| Host Group | Human |
| Host Common name | Human |
| Host Scientific name | Homo sapiens |
| Biomarker Name | IFN-γ |
| Biomarker Full Name | Interferon gamma |
| Biomarker Type | Diagnostic |
| Biomolecule | Protein |
| Geographical Location | USA |
| Cohort | This study used 2 Brigham and Women’s Hospital (BWH) registries of critically ill patients. Patients admitted to the ICU within the past 48 hours were enrolled under 2 clinical research protocols approved by the Partners Healthcare Institutional Review Board: protocols 2008P000495 (n= 563) and 2007P000894 (n = 400). |
| Cohort No. | None |
| Age Group | None |
| P Value | None |
| Sensitivity | None |
| Specificity | None |
| Positive Predictive Value | None |
| MIC | None |
| Fold Change | None |
| Pathway | None |
| Disease Introduction Mechanism | None |
| Technique | PCR |
| Analysis Method | qPCR |
| ELISA kits | None |
| Assay Data | None |
| Validation Techniques used | qPCR, Flow Cytometry Analysis |
| Up Regulation Down Regulation | Positive |
| Sequence Data | None |
| External Link | None |
