| DB ID | MyCo_5595 |
| Title | Post-sepsis immunosuppression depends on NKT cell regulation of mTOR/IFN-γ in NK cells |
| Year | 2020 |
| PMID | 32154791 |
| Fungal Diseases involved | Candida infection |
| Associated Medical Condition | Sepsis |
| Genus | None |
| Species | None |
| Organism | None |
| Ethical Statement | The Brigham and Women’s Hospital IACUC approved our mouse studies in accordance with the NIH Guide for the Care and Use of Laboratory Animals (National Academies Press, 2011) and our institution’s American Association for Laboratory Animal Sci- ence certification. All human studies were approved by the Partners Healthcare Institutional Review Board (Boston, Massachusetts, USA). For human studies, informed consent was received from participants or legal surrogates before inclusion in the study. |
| Site of Infection | None |
| Opportunistic invasive | None |
| Sample type | Body fluid |
| Sample source | Plasma |
| Host Group | Animal |
| Host Common name | Mice |
| Host Scientific name | Mus musculus |
| Biomarker Name | IFN-γ |
| Biomarker Full Name | Interferon gamma |
| Biomarker Type | Diagnostic |
| Biomolecule | Protein |
| Geographical Location | USA |
| Cohort | Here studied 10-week-old mice on a C57BL/6J background, with all strains backcrossed at least 10 generations. Initial experiments used male mice. |
| Cohort No. | None |
| Age Group | None |
| P Value | None |
| Sensitivity | None |
| Specificity | None |
| Positive Predictive Value | None |
| MIC | None |
| Fold Change | None |
| Pathway | None |
| Disease Introduction Mechanism | None |
| Technique | PCR |
| Analysis Method | qPCR |
| ELISA kits | None |
| Assay Data | None |
| Validation Techniques used | qPCR, Flow Cytometry Analysis |
| Up Regulation Down Regulation | Positive |
| Sequence Data | None |
| External Link | None |
