| DB ID | MyCo_5546 |
| Title | Dynamics and prognostic value of plasma cell-free DNA PCR in patients with invasive aspergillosis and mucormycosis |
| Year | 2024 |
| PMID | 38602412 |
| Fungal Diseases involved | Aspergillosis |
| Associated Medical Condition | None |
| Genus | Aspergillus |
| Species | fumigatus |
| Organism | Aspergillus fumigatus |
| Ethical Statement | This study was approved by the Stanford University Institutional Review Board. Informed consent was waived for the utilization of residual discarded plasma samples. |
| Site of Infection | None |
| Opportunistic invasive | None |
| Sample type | Body fluid |
| Sample source | Plasma |
| Host Group | Human |
| Host Common name | Human |
| Host Scientific name | Homo sapiens |
| Biomarker Name | ITS |
| Biomarker Full Name | Internal Transcribed Spacer |
| Biomarker Type | Prognostic |
| Biomolecule | Gene |
| Geographical Location | USA |
| Cohort | In a retrospective cohort study conducted at Stanford Health Care clinical microbiology laboratory, adult and pediatric patients diagnosed with invasive aspergillosis and mucormycosis by Aspergillus and Mucorales plasma cfDNA PCR, respectively, were enrolled in this study, and residual plasma samples were collected prospectively at weekly intervals for a duration of 4 weeks and retested under a research protocol. The primary outcome included an all-cause mortality rate at 6 weeks and 6 months based on baseline CT values (a cutoff of 40 for Aspergillus and 35 for Mucorales) and results of follow-up cfDNA PCR testing. |
| Cohort No. | 45 |
| Age Group | None |
| P Value | p=0.88 |
| Sensitivity | None |
| Specificity | None |
| Positive Predictive Value | None |
| MIC | None |
| Fold Change | None |
| Pathway | None |
| Disease Introduction Mechanism | None |
| Technique | PCR |
| Analysis Method | plasma cell-free DNA (cfDNA) PCR |
| ELISA kits | None |
| Assay Data | None |
| Validation Techniques used | plasma cell-free DNA (cfDNA) PCR |
| Up Regulation Down Regulation | Positive |
| Sequence Data | None |
| External Link | None |
