| DB ID | MyCo_5538 |
| Title | Fungal infection in patients with end-stage liver disease: low frequency or low index of suspicion |
| Year | 2014 |
| PMID | 24726663 |
| Fungal Diseases involved | Fungal infection |
| Associated Medical Condition | End-stage liver disease |
| Genus | None |
| Species | None |
| Organism | None |
| Ethical Statement | This was a prospective study carried out at Assiut University Hospital (AUH), Egypt, from January to August 2013. The study was approved by the ethics committee of AUH. |
| Site of Infection | None |
| Opportunistic invasive | None |
| Sample type | Body fluid |
| Sample source | Serum |
| Host Group | Human |
| Host Common name | Human |
| Host Scientific name | Homo sapiens |
| Biomarker Name | IL-17 |
| Biomarker Full Name | Interleukin-17 |
| Biomarker Type | Diagnostic |
| Biomolecule | Protein |
| Geographical Location | Egypt |
| Cohort | This was a prospective study carried out at Assiut University Hospital (AUH), Egypt, from January to August 2013. Forty-six patients with ESLD were selected from the intensive care unit (ICU) of the Tropical Medicine and Gastroenterology Department, AUH. All patients met the diagnostic criteria for liver cirrhosis by clinical, biochemical, and ultrasonography findings. The severity of liver cirrhosis was assessed according to the Child– Pugh classification and model for end-stage liver disease (MELD) score. |
| Cohort No. | 46 |
| Age Group | None |
| P Value | None |
| Sensitivity | None |
| Specificity | None |
| Positive Predictive Value | None |
| MIC | None |
| Fold Change | None |
| Pathway | None |
| Disease Introduction Mechanism | Invasive fungal infection (IFI) is a serious infection that has a detrimental effect in patients with serious diseases or who are in an immune deficient state. The diagnosis of IFI requires histopathological evidence of tissue invasion, or isolation in blood cultures, or isolation from a normally sterile body fluid or site, with samples collected intraoperatively or by percutaneous needle aspiration. Awareness of IFI has increased in clinical practice with the increased survival of patients in immunocompromised states. Such infections are associated with a high morbidity and significant mortality, requiring early diagnosis and appropriate treatment, but also optimal prophylaxis in patients at high risk. |
| Technique | PCR |
| Analysis Method | PCR Based |
| ELISA kits | None |
| Assay Data | None |
| Validation Techniques used | PCR |
| Up Regulation Down Regulation | Increase |
| Sequence Data | None |
| External Link | None |
