| DB ID | MyCo_5527 |
| Title | Detection of the gp43 gene and (1-3)-beta-D-glucan of Paracoccidioides brasiliensis in the blood of experimentally infected mice |
| Year | 2002 |
| PMID | 11865298 |
| Fungal Diseases involved | Paracoccidioidomycosis |
| Associated Medical Condition | None |
| Genus | Paracoccidioides |
| Species | brasiliensis |
| Organism | Paracoccidioides brasiliensis |
| Ethical Statement | None |
| Site of Infection | None |
| Opportunistic invasive | Opportunistic |
| Sample type | Body fluid |
| Sample source | Blood |
| Host Group | Animal |
| Host Common name | Mice |
| Host Scientific name | Mus musculus |
| Biomarker Name | gp43 |
| Biomarker Full Name | gp43 |
| Biomarker Type | Diagnostic |
| Biomolecule | Gene |
| Geographical Location | Japan |
| Cohort | Specific-pathogen free, 6-week-old, male ddY mice were obtained from Nihon SLC Co., Ltd. (Shizuoka, Japan) . |
| Cohort No. | None |
| Age Group | None |
| P Value | None |
| Sensitivity | None |
| Specificity | None |
| Positive Predictive Value | None |
| MIC | None |
| Fold Change | None |
| Pathway | None |
| Disease Introduction Mechanism | Paracoccidioidomycosis ( PCM ) is caused by Paracoccidioides brasiliensis, a thermo-dependent dimorphic fungus, which is endemic to Latin American countrees and invades the skin, lymph nodes and visceral organs such as lung and central nervous system 1 ) . PCM is uncommon and the diagnosis outside endemic areas is often difficult. For example, most cases of PCM in Japan were believed to be malignant tumor at the time of presentation, and the patients underwent biopsies. |
| Technique | PCR |
| Analysis Method | PCR Based |
| ELISA kits | None |
| Assay Data | BDG commercial kit ( G-test TE, Seikagaku Kogyo K.K., Tokyo, Japan) . |
| Validation Techniques used | PCR, FDA approved Fungitell assay |
| Up Regulation Down Regulation | Positive |
| Sequence Data | None |
| External Link | None |
