| DB ID | MyCo_5515 |
| Title | Fc gamma receptor 3A polymorphism and risk for HIV-associated cryptococcal disease |
| Year | 2013 |
| PMID | 23982074 |
| Fungal Diseases involved | Cryptococcus neoformans infection |
| Associated Medical Condition | HIV-AIDS |
| Genus | Cryptococcus |
| Species | neoformans |
| Organism | Cryptococcus neoformans |
| Ethical Statement | MACS protocols are approved by institutional review boards at each recruitment site, and all participants provided written informed consent. |
| Site of Infection | None |
| Opportunistic invasive | None |
| Sample type | Body fluid |
| Sample source | Serum |
| Host Group | Human |
| Host Common name | Human |
| Host Scientific name | Homo sapiens |
| Biomarker Name | FCGR3A 158V |
| Biomarker Full Name | Fc gamma receptor 3A 158V |
| Biomarker Type | Diagnostic |
| Biomolecule | Protein |
| Geographical Location | USA |
| Cohort | Serum samples (n 164) were obtained from MACS, an ongoing prospective study of the natural and treated histories of HIV infection in homosexual and bisexual men living in Baltimore, Chicago, Pittsburgh, and Los Angeles (29). A total of 6,972 men were enrolled into the MACS between 1984 and 2003. |
| Cohort No. | 164 |
| Age Group | 29-45 |
| P Value | p=0.005 |
| Sensitivity | None |
| Specificity | None |
| Positive Predictive Value | None |
| MIC | None |
| Fold Change | None |
| Pathway | None |
| Disease Introduction Mechanism | Cryptococcus neoformans is the main cause of fungal meningitis in HIV-infected and HIV-uninfected individuals. Human in- fection with C. neoformans, which occurs after acquisition of the fungus from the environment by inhalation, results in a state of latency that is thought to follow colonization of the respiratory tree (1). Most cases of clinically manifest cryptococcal disease (CD) are due to a breakdown in latency, which is most commonly caused by the progressive loss of CD4 T cells that occurs in those with HIV infection (2, 3). However, given that not all HIV- infected individuals with CD4 T cell deficiency develop CD de- spite serological evidence of previous infection (4–7), additional markers are needed to predict CD risk. Such biomarkers could have a major impact by identifying those who would benefit most from targeted prophylaxis and/or earlier treatment. HIV- associated CD remains a major cause of morbidity and mortality globally, particularly in sub-Saharan Africa, where nearly a mil- lion cases and half a million deaths due to CD are estimated to occur annually. |
| Technique | PCR |
| Analysis Method | PCR Based |
| ELISA kits | None |
| Assay Data | None |
| Validation Techniques used | PCR |
| Up Regulation Down Regulation | Positive |
| Sequence Data | None |
| External Link | None |
