| DB ID | MyCo_5494 |
| Title | Antifungal treatment affects the laboratory diagnosis of invasive aspergillosis |
| Year | 2011 |
| PMID | 22049217 |
| Fungal Diseases involved | Invasive aspergillosis |
| Associated Medical Condition | None |
| Genus | Aspergillus |
| Species | fumigatus |
| Organism | Aspergillus fumigatus |
| Ethical Statement | None |
| Site of Infection | None |
| Opportunistic invasive | Invasive |
| Sample type | Body fluid |
| Sample source | Serum |
| Host Group | Animal |
| Host Common name | Mice |
| Host Scientific name | Mus musculus |
| Biomarker Name | 18S rRNA gene + posaconazole |
| Biomarker Full Name | 18S rRNA gene + posaconazole |
| Biomarker Type | Diagnostic |
| Biomolecule | Gene |
| Geographical Location | UK |
| Cohort | A standardised rat inhalation model of aspergillosis was used. Briefly, each animal was immunosuppressed using 75 mg/kg cyclophosphamide and 16 mg/kg depo-medrone. Prophylactic antibiotics (baytril 50 ppm) were added to the drinking water throughout the study. |
| Cohort No. | None |
| Age Group | None |
| P Value | p=0.041 |
| Sensitivity | None |
| Specificity | None |
| Positive Predictive Value | None |
| MIC | None |
| Fold Change | None |
| Pathway | None |
| Disease Introduction Mechanism | Invasive aspergillosis (IA) remains a major concern in the management of patients undergoing haematopoietic stem cell transplantation. As a result of the acknowledged risk of IA a number of strategies have been developed for the use of anti- fungal agents ranging from prophylaxis,1 via preemptive therapy2 to empiric therapy.3 Despite the availability of a number of new mould active antifungal agents IA continues to have a high mortality rate1 and the diagnosis of IA remains problematical4 with many cases not diagnosed until after death. |
| Technique | PCR |
| Analysis Method | PCR Based |
| ELISA kits | None |
| Assay Data | None |
| Validation Techniques used | PCR |
| Up Regulation Down Regulation | Positive |
| Sequence Data | None |
| External Link | None |
