| DB ID | MyCo_5477 |
| Title | Combining standard clinical methods with PCR showed improved diagnosis of invasive pulmonary aspergillosis in patients with hematological malignancies and prolonged neutropenia |
| Year | 2015 |
| PMID | 26126706 |
| Fungal Diseases involved | Invasive pulmonary aspergillosis |
| Associated Medical Condition | Hematological malignancies and prolonged neutropenia |
| Genus | Aspergillus |
| Species | fumigatus |
| Organism | Aspergillus fumigatus |
| Ethical Statement | The study protocol was approved by the ethics committee of the University Hospitals of Debrecen, Hungary. |
| Site of Infection | None |
| Opportunistic invasive | Invasive |
| Sample type | Body fluid |
| Sample source | Serum |
| Host Group | Human |
| Host Common name | Human |
| Host Scientific name | Homo sapiens |
| Biomarker Name | FacC |
| Biomarker Full Name | FacC |
| Biomarker Type | Diagnostic |
| Biomolecule | Gene |
| Geographical Location | Hungary |
| Cohort | Between June 06, 2012 and May 08, 2013, 27 febrile neu-tropenia episodes (FNEs); 16 males with the median age of 42.5 (range 14–75) and 11 females with the median age of 45.5 (range; 19–66) |
| Cohort No. | 27 |
| Age Group | 14-75 |
| P Value | None |
| Sensitivity | None |
| Specificity | None |
| Positive Predictive Value | None |
| MIC | None |
| Fold Change | None |
| Pathway | None |
| Disease Introduction Mechanism | Patients suffering from hematological malignancies and prolonged neutropenia are significantly affected by life- threatening invasive fungal infections, particularly invasive pulmonary aspergillosis (IPA). Despite improvements in transplantation practices and antifungal therapy the treatment of patients with IPA is still challenging. Diagnosis of IPA is difficult and delayed diagnosis contributes to the increasing severity of IPA associated high morbidity and mortality rates. |
| Technique | PCR |
| Analysis Method | FacC-PCR |
| ELISA kits | PlateliaTM Aspergillus EIA assay (Bio-Rad, Munich, Germany) |
| Assay Data | None |
| Validation Techniques used | GM-Platelia™ Aspergillus Ag ELISA, FacC-PCR |
| Up Regulation Down Regulation | Positive |
| Sequence Data | None |
| External Link | None |
