| DB ID | MyCo_5468 |
| Title | Microbiologic Diagnostic Workup of Acute Respiratory Failure with Pulmonary Infiltrates after Allogeneic Hematopoietic Stem Cell Transplantation: Findings in the Era of Molecular- and Biomarker-Based Assays |
| Year | 2018 |
| PMID | 29550627 |
| Fungal Diseases involved | Invasive aspergillosis |
| Associated Medical Condition | Allogeneichematopoieticstemcelltransplantation |
| Genus | Aspergillus |
| Species | spp. |
| Organism | Aspergillus spp. |
| Ethical Statement | The study wasa pproved by the ethics committee of the University of Duisburg-Essen (EC 15 6446- BO) and conducted in accordance with Good Clinical Practice guidelines and the amended Declaration of Helsinki. |
| Site of Infection | None |
| Opportunistic invasive | Invasive |
| Sample type | Body fluid |
| Sample source | Bronchoalveolar lavage fluid (BALF) |
| Host Group | Human |
| Host Common name | Human |
| Host Scientific name | Homo sapiens |
| Biomarker Name | GM |
| Biomarker Full Name | Galactomannan |
| Biomarker Type | Diagnostic |
| Biomolecule | Protein |
| Geographical Location | Germany |
| Cohort | This was a retrospective single-center study of 156 consec- utive HSCT recipients admitted to the intensive care unit (ICU) between May 2013 and July 2017. Findings from a microbiologic diagnostic workup using currently available methods on bronchoalveolar lavage (BAL) andbloodsamplesfrom66patients(age,58years[range,45to64];HSCTtoICU,176days[range,85to407]) with ARF and pulmonary infiltrates were analyzed. In 47 patients (71%) a causative pathogen was identified (fungal, n= 28; viral, n= 26; bacterial, n= 18) |
| Cohort No. | 156 |
| Age Group | 45-64 |
| P Value | p=.049 |
| Sensitivity | None |
| Specificity | None |
| Positive Predictive Value | None |
| MIC | None |
| Fold Change | None |
| Pathway | None |
| Disease Introduction Mechanism | None |
| Technique | PCR |
| Analysis Method | Aspergillus PCR |
| ELISA kits | Platelia™ Aspergillus Ag Kit (BioRad, Hercules, CA, USA) |
| Assay Data | None |
| Validation Techniques used | GM-Platelia™ Aspergillus Ag ELISA, Aspergillus PCR |
| Up Regulation Down Regulation | Positive |
| Sequence Data | None |
| External Link | None |
