| DB ID | MyCo_5459 |
| Title | Galactomannan enzyme immunoassay and quantitative Real Time PCR as tools to evaluate the exposure and response in a rat model of aspergillosis after posaconazole prophylaxis |
| Year | 2016 |
| PMID | 26804792 |
| Fungal Diseases involved | Invasive pulmonary aspergillosis |
| Associated Medical Condition | posaconazole prophylaxis steroid-immunosuppressed rat |
| Genus | Aspergillus |
| Species | fumigatus |
| Organism | Aspergillus fumigatus |
| Ethical Statement | All animal research procedures were approved by the Ethics Committee of Animal Research of the Vall d’Hebrón Hospital (exp. Number PI081206). |
| Site of Infection | None |
| Opportunistic invasive | Invasive |
| Sample type | Biopsy |
| Sample source | Extracted DNA |
| Host Group | Animal |
| Host Common name | Mice |
| Host Scientific name | Mus musculus |
| Biomarker Name | ITS |
| Biomarker Full Name | Internal Transcribed Spacer |
| Biomarker Type | Diagnostic |
| Biomolecule | Gene |
| Geographical Location | Spain |
| Cohort | The study was carried out on an animal model of inva- sive pulmonary aspergillosis riefly, animals were immunosuppressed with subcu- taneous cortisone acetate 125 mg/kg (Sigma, St Louis, MO, USA) three times/week, starting 14 days before the fungal challenge and continuing to the end of the experiment. |
| Cohort No. | None |
| Age Group | None |
| P Value | None |
| Sensitivity | None |
| Specificity | None |
| Positive Predictive Value | None |
| MIC | None |
| Fold Change | None |
| Pathway | None |
| Disease Introduction Mechanism | Invasive aspergillosis (IA) remains a leading cause of infectious disease related to deaths in patients with hematologic malignancies and undergoing hematopoietic stem cell transplantation despite advances in diagnostic tools and treatment options. |
| Technique | PCR |
| Analysis Method | Aspergillus PCR |
| ELISA kits | None |
| Assay Data | None |
| Validation Techniques used | ELISA Based, Aspergillus PCR |
| Up Regulation Down Regulation | Positive |
| Sequence Data | None |
| External Link | None |
