| DB ID | MyCo_5449 |
| Title | In Vivo Biomarker Analysis of the Effects of Intranasally Dosed PC945, a Novel Antifungal Triazole, on Aspergillus fumigatus Infection in Immunocompromised Mice |
| Year | 2017 |
| PMID | 28630185 |
| Fungal Diseases involved | Aspergillus fumigatus infection |
| Associated Medical Condition | None |
| Genus | Aspergillus |
| Species | fumigatus |
| Organism | Aspergillus fumigatus |
| Ethical Statement | All animal studies and class II pathogen use were approved by the Ethics Review Committee for Animal Experimentation of Nihon University and the Microbial Safety Management Committee of the Nihon University School of Pharmacy (E-H25-001). |
| Site of Infection | None |
| Opportunistic invasive | None |
| Sample type | Body fluid |
| Sample source | Bronchoalveolar lavage fluid (BALF) |
| Host Group | Animal |
| Host Common name | Mice |
| Host Scientific name | Mus musculus |
| Biomarker Name | PC945+MDA |
| Biomarker Full Name | PC945+Malondialdehyde |
| Biomarker Type | Diagnostic |
| Biomolecule | Protein |
| Geographical Location | Japan |
| Cohort | None |
| Cohort No. | None |
| Age Group | None |
| P Value | None |
| Sensitivity | None |
| Specificity | None |
| Positive Predictive Value | None |
| MIC | PC945=0.094 |
| Fold Change | None |
| Pathway | None |
| Disease Introduction Mechanism | None |
| Technique | Assay |
| Analysis Method | OxiSelect TBARS Assay |
| ELISA kits | Platelia GM-EIA kits (Bio-Rad Laboratories, Redmond, WA, USA), OxiSelect TBARS (thiobarbituric acid reactive substances) assay kit (MDA quantitation; Cell Biolabs Inc., San Diego, CA, USA), Quantikine mouse enzyme-linked immunosorbent assay (ELISA) kit (R&D Systems Inc., Minneapolis, MN, USA). |
| Assay Data | None |
| Validation Techniques used | GM-Platelia™ Aspergillus Ag ELISA, OxiSelect TBARS Assay, FACS Analysis, ELISA |
| Up Regulation Down Regulation | Decrease |
| Sequence Data | None |
| External Link | None |
