| DB ID | MyCo_5428 |
| Title | Peripheral blood lymphocyte subsets combined with fungal biomarkers in the diagnosis of invasive fungal infections complicated by sepsis |
| Year | 2025 |
| PMID | 39827491 |
| Fungal Diseases involved | Invasive fungal infection |
| Associated Medical Condition | Sepsis |
| Genus | Aspergillus |
| Species | fumigatus |
| Organism | Aspergillus fumigatus |
| Ethical Statement | This study adheres to the ethical standards for medical clinical research and has received approval from the Medical Ethics Committee of the Affiliated Hospital of Integrated Traditional Chinese and Western Medicine of Nanjing University of Chinese Medicine. The ethical approval number is 2023-LWKYZ-011. All procedures were carried out with the informed consent obtained from the patients or their legal representatives. |
| Site of Infection | None |
| Opportunistic invasive | Invasive |
| Sample type | Body fluid |
| Sample source | Serum |
| Host Group | Human |
| Host Common name | Human |
| Host Scientific name | Homo sapiens |
| Biomarker Name | BDG + GM + CD45 |
| Biomarker Full Name | 1-3-beta-D-Glucan + Galactomannan + CD45 |
| Biomarker Type | Diagnostic |
| Biomolecule | Protein |
| Geographical Location | China |
| Cohort | A retrospective case-control study of 47 patients with sepsis complicated by IFIs, 50 sepsis patients, and 50 healthy controls was conducted. |
| Cohort No. | 97 Patients and 50 control |
| Age Group | 60-81 |
| P Value | None |
| Sensitivity | 0.8085 |
| Specificity | 0.96 |
| Positive Predictive Value | None |
| MIC | None |
| Fold Change | None |
| Pathway | None |
| Disease Introduction Mechanism | None |
| Technique | Assay |
| Analysis Method | One-stage immunoenzymatic sandwich microplate assay, Immunoturbidimetry Assay, Flow Cytometry Analysis |
| ELISA kits | None |
| Assay Data | None |
| Validation Techniques used | One-stage immunoenzymatic sandwich microplate assay, Immunoturbidimetry Assay, Flow Cytometry Analysis |
| Up Regulation Down Regulation | Positive |
| Sequence Data | None |
| External Link | None |
