| DB ID | MyCo_5419 |
| Title | Uptake of the Siderophore Triacetylfusarinine C, but Not Fusarinine C, Is Crucial for Virulence of Aspergillus fumigatus |
| Year | 2022 |
| PMID | 36125294 |
| Fungal Diseases involved | Aspergillosis |
| Associated Medical Condition | None |
| Genus | Aspergillus |
| Species | fumigatus |
| Organism | Aspergillus fumigatus |
| Ethical Statement | The protocol was approved by the Minister of Health (MOH) Animal Welfare Committee, Israel (protocol number MOH 01-17-035). All efforts were made to minimize the number of animals used and animal suffering. |
| Site of Infection | None |
| Opportunistic invasive | None |
| Sample type | Biopsy |
| Sample source | Extracted RNA |
| Host Group | Animal |
| Host Common name | Mice |
| Host Scientific name | Mus musculus |
| Biomarker Name | mirB |
| Biomarker Full Name | mirB [AFUA_3G03640/AFUB_044500] |
| Biomarker Type | Diagnostic |
| Biomolecule | Gene |
| Geographical Location | Austria |
| Cohort | Six-week-old female ICR mice were immuno- compromised by two subcutaneous injections with 300 mg/kg of body weight of cortisone acetate, given 3 days before infection and on the day of infection. The mice were anesthetized by intraperitoneal (i.p.) injection with 100 mg/kg ketamine–10 mg/kg xylazine and infected intranasally with 5 105 dor- mant spores/mouse, suspended in 20 mL of 0.2% Tween 20 in a saline solution (0.9% [wt/vol] NaCl), with 10 mL in each nostril. Endpoints for sacri ce included a drop of .15% in body weight or signs of acute distress. Mice were monitored for up to 21 days. |
| Cohort No. | None |
| Age Group | None |
| P Value | None |
| Sensitivity | None |
| Specificity | None |
| Positive Predictive Value | None |
| MIC | None |
| Fold Change | None |
| Pathway | None |
| Disease Introduction Mechanism | None |
| Technique | Analytic |
| Analysis Method | Northern blotting |
| ELISA kits | None |
| Assay Data | None |
| Validation Techniques used | Northern blotting |
| Up Regulation Down Regulation | Positive |
| Sequence Data | None |
| External Link | None |
