| DB ID | MyCo_5304 |
| Title | Intrathecal IgG Synthesis and Persistent Inflammation Are Associated with White Matter Lesions in HIV-negative Patients with Cryptococcal Meningoencephalitis |
| Year | 2019 |
| PMID | 31243232 |
| Fungal Diseases involved | Cryptococcal meningoencephalitis |
| Associated Medical Condition | White Matter Lesions |
| Genus | Cryptococcus |
| Species | neoformans |
| Organism | Cryptococcus neoformans |
| Ethical Statement | Each participating hospital received either human research approval to enroll patients without individual patient consent under the Common Rule or a waiver of authorization and exemption from subsequent review by the ethics committees of Tokyo Medical and Dental University, Yokosuka Kyosai Hospital, and Tsuchiura Kyodo General Hospital. The study was conducted in compliance with the Declaration of Hel-sinki. |
| Site of Infection | None |
| Opportunistic invasive | None |
| Sample type | Body fluid |
| Sample source | Cerebrospinal fluid (CSF) |
| Host Group | Human |
| Host Common name | Human |
| Host Scientific name | Homo sapiens |
| Biomarker Name | CSF IgG |
| Biomarker Full Name | Cerebrospinal fluid immunoglobulin G |
| Biomarker Type | Diagnostic |
| Biomolecule | Protein |
| Geographical Location | Japan |
| Cohort | This was a retrospective study conducted in Japan at Tokyo Medical and Dental University, Yokosuka Kyosai Hospital and Tsuchiura Kyodo General Hospital between April 2001 and March 2018. Eleven consecutive HIV-negative patients with CM who presented at one of three emergency hospitals in Japan from April 2001 to March 2018 were enrolled. |
| Cohort No. | 11 |
| Age Group | 29-89 |
| P Value | None |
| Sensitivity | None |
| Specificity | None |
| Positive Predictive Value | None |
| MIC | None |
| Fold Change | None |
| Pathway | None |
| Disease Introduction Mechanism | Cryptococcal meningoencephalitis (CM) is a life- threatening fungal infection of the central nervous system (CNS). Although CM is common in human immunodefi-ciency virus (HIV)-positive patients, HIV-negative CM pa-tients have also been increasingly frequently encountered be-cause of the widespread use of immunologic drugs againstcancers and autoimmune disorders and the prevalence of diabetes mellitus, chronic liver and renal diseases especially in developed countries. |
| Technique | Analytic |
| Analysis Method | MRI (magnetic resonance imaging) |
| ELISA kits | None |
| Assay Data | None |
| Validation Techniques used | MRI Analysis |
| Up Regulation Down Regulation | Increase |
| Sequence Data | None |
| External Link | None |
