| DB ID | MyCo_5249 |
| Title | Metabolomics Analysis Reveals Specific Novel Tetrapeptide and Potential Anti-Inflammatory Metabolites in Pathogenic Aspergillus species |
| Year | 2015 |
| PMID | 26090713 |
| Fungal Diseases involved | Invasive aspergillosis |
| Associated Medical Condition | None |
| Genus | Aspergillus |
| Species | terreus |
| Organism | Aspergillus terreus |
| Ethical Statement | None |
| Site of Infection | None |
| Opportunistic invasive | Invasive |
| Sample type | Extracted Conidia |
| Sample source | Extracted conidia |
| Host Group | None |
| Host Common name | None |
| Host Scientific name | None |
| Biomarker Name | Hydroxy-(sulfooxy)benzoic acid |
| Biomarker Full Name | Hydroxy-(sulfooxy)benzoic acid |
| Biomarker Type | Diagnostic |
| Biomolecule | Metabolite |
| Geographical Location | Hong Kong |
| Cohort | Thirty Aspergillus strains of A. fumigatus, A. flavus, A. niger, A. terreus, A. nomius and A. tamarii; and 34 non-Aspergillus fungal strains, belonging to C. neoformans, M. pilosus, C. albicans, P. parasiticum, P. marneffei, T. rubrum, T. interdigitale and Lichtheimia species, were included in this study. |
| Cohort No. | None |
| Age Group | None |
| P Value | None |
| Sensitivity | None |
| Specificity | None |
| Positive Predictive Value | None |
| MIC | None |
| Fold Change | None |
| Pathway | None |
| Disease Introduction Mechanism | In recent years, infections related to Aspergillus species have become an emerging focus of clinical microbiology and infectious disease as the number of patients infected with Aspergillus species rose dramatically. In immunocompetent and mildly immunocompromised hosts, Aspergillus species rarely cause serious illnesses, except for pulmonary aspergilloma in patients with pre-existing chronic lung diseases and, less commonly, chronic cavitary pulmonary aspergillosis, chronic fibrosing aspergillosis and chronic necrotizing aspergillosis. On the other hand, invasive aspergillosis is one of the most important causes of morbidity and mortality in immunocompromised patients, such as those with hematological malignancies undergoing chemotherapy, hematopoietic stem cell and solid organ transplantation and HIV infection. Among the known Aspergillus species, Aspergillus fumigatus is the most common species causing human infections in western countries, whereas Aspergillus flavus is as important as A. fumigatus in our locality and in other Asian countries, and is the second most common Aspergillus species associated with human infections in western countries. Other Aspergillus species commonly associated with human infections include Aspergillus niger and Aspergillus terreus. |
| Technique | Analytic |
| Analysis Method | UHPLC–ESI-Q-TOF-MS |
| ELISA kits | None |
| Assay Data | None |
| Validation Techniques used | UHPLC–ESI-Q-TOF-MS |
| Up Regulation Down Regulation | Positive |
| Sequence Data | None |
| External Link | None |
