| DB ID | MyCo_5179 |
| Title | Monitoring of extracellular matrix metabolism and cross-linking in tissue, serum and urine of patients with chromoblastomycosis, a chronic skin fibrosis |
| Year | 1998 |
| PMID | 9767374 |
| Fungal Diseases involved | Chromoblastomycosis |
| Associated Medical Condition | Dermal fibrosis |
| Genus | Fonsecaea |
| Species | pedrosoi |
| Organism | Fonsecaea pedrosoi |
| Ethical Statement | The study was approved by the Malagasy Ministry of Health and was conducted arrording to the ethical requirements. |
| Site of Infection | None |
| Opportunistic invasive | None |
| Sample type | Body fluid |
| Sample source | Urine |
| Host Group | Human |
| Host Common name | Human |
| Host Scientific name | Homo sapiens |
| Biomarker Name | Pyridinoline |
| Biomarker Full Name | Pyridinoline |
| Biomarker Type | Diagnostic |
| Biomolecule | Metabolite |
| Geographical Location | Malagasy |
| Cohort | The trial design included treatment with terbinafine (Lami sil, Novartis, Rueil-Malmaison, France) 500 mg daily for 1 year. The efficiency of the treatment was evaluated by examination of skin scrapings, mycological cultures or histopathology. |
| Cohort No. | None |
| Age Group | None |
| P Value | p=0.04 |
| Sensitivity | None |
| Specificity | None |
| Positive Predictive Value | None |
| MIC | None |
| Fold Change | None |
| Pathway | None |
| Disease Introduction Mechanism | Chromoblastomycosis is a cutaneous fungal infection characterized by dermal fibrosis, and worldwide this debilitating disease is most endemic in Madagascar. This chronic mycosis begins with one or more nodules that subsequently develop a verrucous or papillomatous lesion, often with superimposed bacterial infection. Histological examination reveals a granulomatous reaction associated with a pseudoepitheliomatous hyperplasia of the epidermis. |
| Technique | Liquid chromatography |
| Analysis Method | Metabolomics Approach |
| ELISA kits | None |
| Assay Data | None |
| Validation Techniques used | Metabolomics Approach |
| Up Regulation Down Regulation | Increase |
| Sequence Data | None |
| External Link | None |
