| DB ID | MyCo_5151 |
| Title | Clinical validity of bis(methylthio)gliotoxin for the diagnosis of invasive aspergillosis |
| Year | 2016 |
| PMID | 26678078 |
| Fungal Diseases involved | Invasive aspergillosis |
| Associated Medical Condition | None |
| Genus | Aspergillus |
| Species | flavus |
| Organism | Aspergillus flavus |
| Ethical Statement | The study was approved by the local ethics committee CEICA (PI12/0041 and PI15/0197). |
| Site of Infection | None |
| Opportunistic invasive | Invasive |
| Sample type | Body fluid |
| Sample source | Serum |
| Host Group | Human |
| Host Common name | Human |
| Host Scientific name | Homo sapiens |
| Biomarker Name | bmGT |
| Biomarker Full Name | Bis(methylthio)gliotoxin |
| Biomarker Type | Diagnostic |
| Biomolecule | Protein |
| Geographical Location | Spain |
| Cohort | Patients hospitalized in a tertiary care center to whom GM detection was requested from May to December 2013 were included in the study. During the study period, a total of 357 sera from the 79 patients fulfilling inclusion criteria were analyzed. |
| Cohort No. | 79 |
| Age Group | 64.9 ± 16.9 |
| P Value | p=0.17 |
| Sensitivity | 0.556 |
| Specificity | 0.922 |
| Positive Predictive Value | 0.156 |
| MIC | None |
| Fold Change | None |
| Pathway | None |
| Disease Introduction Mechanism | Invasive aspergillosis (IA) is a severe opportunistic infection with high morbidity and mortality rates caused by fungi of the genus Aspergillus, which mainly affects neutropenic patients. The high mortality rates are in part due to deficiencies associated with early and specific diagnosis. |
| Technique | Liquid chromatography |
| Analysis Method | Metabolomics Approach |
| ELISA kits | Platelia™ Aspergillus Ag Kit (BioRad, Hercules, CA, USA) |
| Assay Data | None |
| Validation Techniques used | ELISA, High-performance thin layer chromatography (HPTLC) |
| Up Regulation Down Regulation | Increase |
| Sequence Data | None |
| External Link | None |
