| DB ID | MyCo_4977 |
| Title | Diagnostic efficacy of serum cytokines and chemokines in fungal bloodstream infection in febrile patients |
| Year | 2020 |
| PMID | 31971308 |
| Fungal Diseases involved | Fungemia |
| Associated Medical Condition | febrile patients |
| Genus | Candida |
| Species | albicans |
| Organism | Candida albicans |
| Ethical Statement | This study was reviewed and approved by the Ethics Committee of Chinese PLA General Hospital (S2018-207-02). |
| Site of Infection | None |
| Opportunistic invasive | None |
| Sample type | Body fluid |
| Sample source | Serum |
| Host Group | Human |
| Host Common name | Human |
| Host Scientific name | Homo sapiens |
| Biomarker Name | IL-10 |
| Biomarker Full Name | Interleukin-10 |
| Biomarker Type | Diagnostic |
| Biomolecule | Protein |
| Geographical Location | China |
| Cohort | Patients with blood cultures that yielded fungi and patients with negative blood culture results were included in our study. All these enrolled patients were suspected of infection due to their increased temperature from fever clinics or different departments of Chinese PLA General Hospital between January 2016 and December 2018. In total, fourteen types of serum cytokines and chemokines from 41 patients with fungemia were compared with 57 patients with negative blood culture results. |
| Cohort No. | 41 Patients and 51 control |
| Age Group | 58.63±21.97 and 63.78±19.16 |
| P Value | p<.001 |
| Sensitivity | 0.778 |
| Specificity | 0.75 |
| Positive Predictive Value | None |
| MIC | None |
| Fold Change | None |
| Pathway | None |
| Disease Introduction Mechanism | Increasing incidence of fungemia among nosocomial bloodstream infections has been observed over the recent years due to increase of immunocompromised individuals with systemic diseases such as diabetes mellitus and acquired immune deficiency syndrome. Fungemia is a life-threatening condition with the global mortality rate surging more than fivefold in the past decade. It has been re- ported that the outcome depends on early and targeted treatment; thus, prompt diagnosis is essential at the early stage of infection. |
| Technique | Analytic |
| Analysis Method | Luminex® xMAP Bead Array Platform analysis |
| ELISA kits | None |
| Assay Data | None |
| Validation Techniques used | Luminex® xMAP Bead Array Platform analysis |
| Up Regulation Down Regulation | Up regulated |
| Sequence Data | None |
| External Link | None |
