| DB ID | MyCo_4786 |
| Title | Tracheal colonization factor A (TcfA) is a biomarker for rapid and specific detection of Bordetella pertussis |
| Year | 2020 |
| PMID | 32929160 |
| Fungal Diseases involved | Pertussis |
| Associated Medical Condition | None |
| Genus | Bordetella |
| Species | pertussis |
| Organism | Bordetella pertussis |
| Ethical Statement | Immunization of rabbits for polyclonal antibody (pAb) production and of mice for MAb production was approved by the University of Nevada, Reno Institutional Animal Care and Use Committee (IACUC); all experiments were performed in accordance with relevant guidelines and regulations. |
| Site of Infection | Lungs |
| Opportunistic invasive | None |
| Sample type | Body fluid |
| Sample source | Nasopharyngeal Swab Specimens |
| Host Group | Human |
| Host Common name | Human |
| Host Scientific name | Homo sapiens |
| Biomarker Name | TcfA |
| Biomarker Full Name | Tracheal Colonization Factor A |
| Biomarker Type | Diagnostic |
| Biomolecule | Protein |
| Geographical Location | USA |
| Cohort | Pertussis (whooping cough) is a serious respiratory disease caused by Bordetella pertussis. It is airborne, highly contagious, and responsible for an annual 18.4 million illnesses and 254,000 deaths worldwide. Despite high vaccine coverage, pertussis has persisted in the United States with recent peaks of approximately 48,000 reported cases in 2012 and 33,000 cases in 2014. Moreover, reported cases likely underestimate the true number of infections. |
| Cohort No. | None |
| Age Group | None |
| P Value | None |
| Sensitivity | None |
| Specificity | None |
| Positive Predictive Value | None |
| MIC | None |
| Fold Change | None |
| Pathway | None |
| Disease Introduction Mechanism | Pertussis (whooping cough) is a serious respiratory disease caused by Bordetella pertussis. It is airborne, highly contagious, and responsible for an annual 18.4 million illnesses and 254,000 deaths worldwide. Despite high vaccine coverage, pertussis has persisted in the United States with recent peaks of approximately 48,000 reported cases in 2012 and 33,000 cases in 2014. Moreover, reported cases likely underestimate the true number of infections. |
| Technique | ELISA |
| Analysis Method | LIFA ELISA Assay |
| ELISA kits | None |
| Assay Data | None |
| Validation Techniques used | FDA Approved ELISA |
| Up Regulation Down Regulation | None |
| Sequence Data | None |
| External Link | None |
