| DB ID | MyCo_4439 |
| Title | Prevalence, determinants of positivity, and clinical utility of cryptococcal antigenemia in Cambodian HIV-infected patients |
| Year | 2007 |
| PMID | 17577124 |
| Fungal Diseases involved | Cryptococcosis |
| Associated Medical Condition | HIV-AIDS |
| Genus | Cryptococcus |
| Species | neoformans |
| Organism | Cryptococcus neoformans |
| Ethical Statement | This study was approved by the National Ethics Committee for Health Research of the Cambodia Ministry of Health. |
| Site of Infection | None |
| Opportunistic invasive | None |
| Sample type | Body fluid |
| Sample source | Serum |
| Host Group | Human |
| Host Common name | Human |
| Host Scientific name | Homo sapiens |
| Biomarker Name | CPS |
| Biomarker Full Name | cryptococcal polysaccharide |
| Biomarker Type | Diagnostic |
| Biomolecule | Protein |
| Geographical Location | France |
| Cohort | Between April and November 2004, 441 HIV-infected patients aged 18 years or older with a median CD4 count of 31.5 (interquartile range [IQR]: 9 to 125) cells/mm3 were seen in the 2 hospitals participating in the study (N = 327). |
| Cohort No. | 327 |
| Age Group | 31- 40 |
| P Value | None |
| Sensitivity | None |
| Specificity | None |
| Positive Predictive Value | None |
| MIC | None |
| Fold Change | None |
| Pathway | None |
| Disease Introduction Mechanism | Cyptococcal infection is a common opportunistic infec- tion among severely immunosuppressed HIV-infected patients. In highly endemic countries like Thailand, its prev- alence among AIDS patients ranges from 18% to 36%1,2 and its yearly incidence among HIV-infected individuals without highly active antiretroviral therapy (HAART) is estimated at 8.8 per 100 person-years.3 In Cambodia, it was a leading cause of mortality among AIDS patients hospitalized in Phnom Penh in the late 1990s. |
| Technique | Assay |
| Analysis Method | Latex agglutination tests |
| ELISA kits | Latex Agglutination System (CALAS; Meridian Bioscience Europe, Nice, France) |
| Assay Data | None |
| Validation Techniques used | Latex agglutination tests |
| Up Regulation Down Regulation | Positive |
| Sequence Data | None |
| External Link | None |
