| DB ID | MyCo_4433 |
| Title | Cost-effectiveness of CRAG-LFA screening for cryptococcal meningitis among people living with HIV in Uganda |
| Year | 2017 |
| PMID | 28335769 |
| Fungal Diseases involved | Cryptococcal meningitis |
| Associated Medical Condition | HIV-AIDS |
| Genus | Cryptococcus |
| Species | spp. |
| Organism | Cryptococcus spp. |
| Ethical Statement | This study was deemed exempt from IRB approval. |
| Site of Infection | None |
| Opportunistic invasive | None |
| Sample type | None |
| Sample source | None |
| Host Group | Human |
| Host Common name | Human |
| Host Scientific name | Homo sapiens |
| Biomarker Name | Cryptococcal antigen |
| Biomarker Full Name | Cryptococcal antigen |
| Biomarker Type | Diagnostic |
| Biomolecule | Protein |
| Geographical Location | USA |
| Cohort | A decision-analytic model was constructed to compare two strategies for cryptococcal prevention among people living with HIV with CD4 < 100 in Uganda: No cryptococcal screening vs. CRAG screening with WHO- recommended preemptive treatment for CRAG-positive patients. |
| Cohort No. | None |
| Age Group | None |
| P Value | None |
| Sensitivity | None |
| Specificity | None |
| Positive Predictive Value | None |
| MIC | None |
| Fold Change | None |
| Pathway | None |
| Disease Introduction Mechanism | Cryptococcal meningitis (CM) constitutes a significant source of global morbidity and mortality for people living with HIV (PLWH), particularly in resource limited settings. Nearly 1 million cases of cryptococcal disease with 625,000 deaths are estimated to occur annually, sur- passing tuberculosis and other opportunistic infections in some highly prevalent areas. Of these, the vast majority of cases occur in sub-Saharan Africa, where CM is the cause of 10–44% of HIV-associated deaths. |
| Technique | Assay |
| Analysis Method | Lateral Flow Assay |
| ELISA kits | None |
| Assay Data | cryptococcal antigen Lateral Flow Assay (IMMY CrAg LFA, Norman, OK, 2011) |
| Validation Techniques used | Lateral Flow Assay |
| Up Regulation Down Regulation | Positive |
| Sequence Data | None |
| External Link | None |
