| DB ID | MyCo_4179 |
| Title | Macrophage immunophenotypes in Jorge Lobo's disease and lepromatous leprosy- A comparative study |
| Year | 2024 |
| PMID | 38484920 |
| Fungal Diseases involved | Jorge Lobo’s disease |
| Associated Medical Condition | Lepromatous leprosy |
| Genus | None |
| Species | None |
| Organism | None |
| Ethical Statement | The Institutional Review Board approved this retrospective and analytical study before data gathering began. |
| Site of Infection | Skin |
| Opportunistic invasive | None |
| Sample type | Skin swab |
| Sample source | Skin swab |
| Host Group | Human |
| Host Common name | Human |
| Host Scientific name | Homo sapiens |
| Biomarker Name | HAM 56 |
| Biomarker Full Name | HAM 56 |
| Biomarker Type | Diagnostic |
| Biomolecule | Protein |
| Geographical Location | Brazil |
| Cohort | All skin samples from patients with JLD from 2005 to 2017 were retrieved. Skin samples of 52 JLD patients and 16 LL patients were selected. There was a predominance of males (JLD =84.6%; LL = 87.5%); the mean age was 51 years in the JLD group and 51.25 in the LL group. |
| Cohort No. | 68 |
| Age Group | 51-51.25 |
| P Value | p=0.041 |
| Sensitivity | None |
| Specificity | None |
| Positive Predictive Value | None |
| MIC | None |
| Fold Change | None |
| Pathway | None |
| Disease Introduction Mechanism | Jorge Lobo’s disease (JLD) is a chronic cutaneous and subcutaneous fungal granulomatous disease first described in 1931. It is caused by Paracoccidioides lobogeorgii (formerly Lacazia loboi), an uncultivable fungal pathogen, and lepromatous leprosy (LL), a millenary disease caused by the Mycobacterium leprae complex bacteria, which is also uncultivable. They share several clinical, histological and immunopathogenic features. Both are prevalent diseases in the Brazilian Amazon. In JLD, typical skin lesions are nodular and keloidal, and in LL, they are indurated plaques and nodules (lepromas). In both diseases the ability to react to the etiological agent is spectral; many individuals from the same family, geographic region and occupations do not become infected, while others develop a more limited disease, and still others are more severely affected. |
| Technique | Immunological assay |
| Analysis Method | Immunophenotypic profiles |
| ELISA kits | None |
| Assay Data | None |
| Validation Techniques used | Immunophenotypic profiles |
| Up Regulation Down Regulation | Increase |
| Sequence Data | None |
| External Link | None |
