| DB ID | MyCo_4030 |
| Title | The pattern of immune cell infiltration in chromoblastomycosis: involvement of macrophage inflammatory protein-1 alpha/CCL3 and fungi persistence |
| Year | 2007 |
| PMID | 17384820 |
| Fungal Diseases involved | Chromoblastomycosis |
| Associated Medical Condition | None |
| Genus | None |
| Species | None |
| Organism | None |
| Ethical Statement | All samples were obtained under institutionally approved protocols of the School of Medicine Ethical Committee, University of Brasilia. |
| Site of Infection | None |
| Opportunistic invasive | None |
| Sample type | Biopsy |
| Sample source | Extracted tissue |
| Host Group | Human |
| Host Common name | Human |
| Host Scientific name | Homo sapiens |
| Biomarker Name | CD20+ |
| Biomarker Full Name | CD20+ |
| Biomarker Type | Diagnostic |
| Biomolecule | Protein |
| Geographical Location | Brazil |
| Cohort | Biopsies were obtained from 10 patients with clinical and histopathological diagnosis of CR before the beginning of treatment for diagnostic purposes. |
| Cohort No. | 10 |
| Age Group | 52-73 |
| P Value | p=0.012 |
| Sensitivity | None |
| Specificity | None |
| Positive Predictive Value | None |
| MIC | None |
| Fold Change | None |
| Pathway | None |
| Disease Introduction Mechanism | Chromoblastomycosis (CR) is a chronic skin infection caused by various members of the Dematiaceae family, including Fonsecaea pedrosoi, Phialophora verrucosa, Fonsecaea compactum, Cladosporium carrioni, Rinocladiella aquaspersa. Histopathologic findings of CR include pseudo-epitheliomatous epidermal hyperplasia, hyperkeratosis, irregular acanthosis, alternating with areas of atrophy and collection of inflammatory cells forming epidermic abscesses. At the dermal level, a granulomatous reaction with different grades of fibrosis can be observed. Fungi may be observed among these structures or, more frequently, in the interior of the giant cells, under the form of round hazel cells containing a distinct membrane. Besides the presence of macrophages, T lymphocytes (CD4+ and CD8+), B lymphocytes, Langerhans’ cells and epithelioid cells in the granulomas, a vast amount of polymorphonuclear (PMN) cells and eosinophils infiltrating in the lesion can be observed. |
| Technique | Immunological assay |
| Analysis Method | Immunohistochemistry Analysis |
| ELISA kits | None |
| Assay Data | None |
| Validation Techniques used | Immunohistochemistry Analysis |
| Up Regulation Down Regulation | Increase |
| Sequence Data | None |
| External Link | None |
