| DB ID | MyCo_4015 |
| Title | M2 macrophages and inflammatory cells in oral lesions of chronic paracoccidioidomycosis |
| Year | 2015 |
| PMID | 26041558 |
| Fungal Diseases involved | Paracoccidioidomycosis |
| Associated Medical Condition | None |
| Genus | Paracoccidioides |
| Species | brasiliensis |
| Organism | Paracoccidioides brasiliensis |
| Ethical Statement | All cases diagnosed as oral PCM from 1998 to 2011 by the Laboratory of Oral Pathology had their data collected after approval of Human Research Ethics Committee of Federal University of Alfenas (Protocol #271.247). |
| Site of Infection | None |
| Opportunistic invasive | None |
| Sample type | Biopsy |
| Sample source | Extracted tissue |
| Host Group | Human |
| Host Common name | Human |
| Host Scientific name | Homo sapiens |
| Biomarker Name | IL-1β |
| Biomarker Full Name | Interleukin-1β |
| Biomarker Type | Diagnostic |
| Biomolecule | Protein |
| Geographical Location | Brazil |
| Cohort | All cases diagnosed as oral PCM from 1998 to 2011 by the Laboratory of Oral Pathology had their data collected after approval of Human Research Ethics Committee of Federal University of Alfenas (Protocol #271.247). Forty-eight cases of chronic PCM oral lesions were included. |
| Cohort No. | 48 |
| Age Group | None |
| P Value | p=0.003 |
| Sensitivity | None |
| Specificity | None |
| Positive Predictive Value | None |
| MIC | None |
| Fold Change | None |
| Pathway | None |
| Disease Introduction Mechanism | Paracoccidioidomycosis (PCM) is an infection caused by the dimorphic fungus Paracoccidioides brasiliensis (Pb) found in the soil of Latin America countries from Mexico to South of Argentina, and endemic in Brazilian Central-West, Southeast, and South regions. It represents the main cause of disabilities and death among young adult country- side workers with age varying from 29 to 40 years old, during their most productive lifespan. The main form of PCM infection occurs by the inhalation of fungi spores. Initially, the disease affects the lungs, and later, it can disseminate to other organs and tissues and result in secondary lesions in mucosal membranes (oral and nasal). The clinical evolution of PCM can be acute (juvenile) or chronic (adult); both are associated with systemic infections and de cient immune cell response. |
| Technique | Immunological assay |
| Analysis Method | Immunohistochemistry Analysis |
| ELISA kits | None |
| Assay Data | None |
| Validation Techniques used | Immunohistochemistry Analysis |
| Up Regulation Down Regulation | Increase |
| Sequence Data | None |
| External Link | None |
