| DB ID | MyCo_4014 |
| Title | Dendritic cells and pattern of cytokines in paracoccidioidomycosis skin lesions |
| Year | 2003 |
| PMID | 12652191 |
| Fungal Diseases involved | Paracoccidioidomycosis |
| Associated Medical Condition | None |
| Genus | Paracoccidioides |
| Species | brasiliensis |
| Organism | Paracoccidioides brasiliensis |
| Ethical Statement | None |
| Site of Infection | None |
| Opportunistic invasive | None |
| Sample type | Biopsy |
| Sample source | Extracted skin tissue |
| Host Group | Human |
| Host Common name | Human |
| Host Scientific name | Homo sapiens |
| Biomarker Name | IL-10 |
| Biomarker Full Name | Interleukin-10 |
| Biomarker Type | Diagnostic |
| Biomolecule | Protein |
| Geographical Location | Brazil |
| Cohort | Sixty-one skin biopsies from patients with a clinical diagnosis of PCM confirmed by direct examination or fungal culture were selected from the files of the Der- matopathology Laboratory of the Department of Derma- tology of the University of São Paulo Medical School according to the amount of tissue available to perform all the proposed immunohistochemical techniques. |
| Cohort No. | 61 |
| Age Group | None |
| P Value | None |
| Sensitivity | None |
| Specificity | None |
| Positive Predictive Value | None |
| MIC | None |
| Fold Change | None |
| Pathway | None |
| Disease Introduction Mechanism | Paracoccidioidomycosis (PCM) is a human systemic mycosis caused by the dimorphic fungus Paracoccidioi- des brasiliensis. It is confined to Latin America, with endemic areas in Brazil, Argentina, Colombia, and Ven- ezuela. Primary lesions are thought to occur in the lungs. From these lesions, the fungi can disseminate via the bloodstream or lymphatics to any organ of the host, and the skin is involved in approximately 50% of cases. Cutaneous lesions constitute an important clinical ele- ment of the diagnosis because they represent an exteri- orization of the disease. |
| Technique | Immunological assay |
| Analysis Method | Immunohistochemistry Analysis |
| ELISA kits | None |
| Assay Data | None |
| Validation Techniques used | Immunohistochemistry Analysis |
| Up Regulation Down Regulation | Positive |
| Sequence Data | None |
| External Link | None |
