| DB ID | MyCo_4012 |
| Title | Expression of adhesion molecules in lungs of mice infected with Paracoccidioides brasiliensis conidia |
| Year | 2005 |
| PMID | 15857804 |
| Fungal Diseases involved | Paracoccidioidomycosis |
| Associated Medical Condition | None |
| Genus | Paracoccidioides |
| Species | brasiliensis |
| Organism | Paracoccidioides brasiliensis |
| Ethical Statement | None |
| Site of Infection | Skin |
| Opportunistic invasive | None |
| Sample type | Biopsy |
| Sample source | Extracted Tissue |
| Host Group | Animal |
| Host Common name | Mice |
| Host Scientific name | Mus musculus |
| Biomarker Name | ICAM-1 |
| Biomarker Full Name | ICAM-1 |
| Biomarker Type | Diagnostic |
| Biomolecule | Protein |
| Geographical Location | Colombia, South America |
| Cohort | Isogenic 6-week-old BALB/c male mice, obtained from the breeding colony of the Corporación para Investigaciones Biológicas (CIB), Medellín, Colombia, were used in all experiments |
| Cohort No. | None |
| Age Group | None |
| P Value | None |
| Sensitivity | None |
| Specificity | None |
| Positive Predictive Value | None |
| MIC | None |
| Fold Change | None |
| Pathway | None |
| Disease Introduction Mechanism | Paracoccidioidomycosis (PCM) is a systemic mycosis restricted to Latin America, reported mainly in Brazil, Colom- bia and Venezuela. The disease, caused by the dimor- phic fungus Paracoccidioides brasiliensis, is usually a pro- gressive chronic illness that primarily involves the lungs and disseminates to several organs and systems. Rarely, the initial pulmonary infection outweighs the host’s immune defenses, causing an acute-subacute disease, the juvenile type, that predominantly involves the reticuloendothelial system. Nevertheless, the commonest clinical presentation is the chronic form, or adult type disease. |
| Technique | Immunological assay |
| Analysis Method | Immunohistochemistry Analysis |
| ELISA kits | None |
| Assay Data | None |
| Validation Techniques used | Immunohistochemistry Analysis |
| Up Regulation Down Regulation | Positive |
| Sequence Data | None |
| External Link | None |
