| DB ID | MyCo_4003 |
| Title | Translationally controlled tumor protein from Madurella mycetomatis, a marker for tumorous mycetoma progression |
| Year | 2006 |
| PMID | 16849514 |
| Fungal Diseases involved | Madurella mycetomatis infection |
| Associated Medical Condition | None |
| Genus | Madurella |
| Species | mycetomatis |
| Organism | Madurella mycetomatis |
| Ethical Statement | Permission for animal experiments was granted by the Animal Ethics Committee of Erasmus MC. |
| Site of Infection | None |
| Opportunistic invasive | None |
| Sample type | Body fluid |
| Sample source | Serum |
| Host Group | Animal |
| Host Common name | Mice |
| Host Scientific name | Mus musculus |
| Biomarker Name | TCTP |
| Biomarker Full Name | Translationally Controlled Tumor Protein |
| Biomarker Type | Diagnostic |
| Biomolecule | Protein |
| Geographical Location | Netherlands |
| Cohort | Mice sera were obtained by infecting female BALB/c mice i.p. with 140 mg of sonicated wet weight mycelia of the strain. The sera from 10 infected mice were pooled and used in the experiments. |
| Cohort No. | 10 |
| Age Group | None |
| P Value | None |
| Sensitivity | None |
| Specificity | None |
| Positive Predictive Value | None |
| MIC | None |
| Fold Change | None |
| Pathway | None |
| Disease Introduction Mechanism | Madurella mycetomatis is a fungus capable of inducing eumycetoma in humans. Eumycetoma is a major mycological health problem of severe morbidity in tropical and subtropical areas. The disease is characterized by extensive tumor-like s.c. masses and discharge of fungal grains, blood, and pus and primarily affects the earning members of the society. Treatment of advanced cases usually implies amputa- tion of the infected limb. This disease has been reported in many countries including Sudan, Somalia, Senegal, Mauritania, Kenya, Ni- ger, Nigeria, Ethiopia, Chad, Cameroon, Djibouti, India, Yemen, Mexico, Venezuela, Columbia, and Argentina. In Sudan alone, within 2.5 years 1231 mycetoma cases were recorded. |
| Technique | Immunological assay |
| Analysis Method | Immunohistochemistry Analysis |
| ELISA kits | None |
| Assay Data | None |
| Validation Techniques used | Immunohistochemistry Analysis |
| Up Regulation Down Regulation | Positive |
| Sequence Data | Peptide6-TKAQAYVKDTVLP |
| External Link | None |
