| DB ID | MyCo_3993 |
| Title | Analysis of microvasculature phenotype and endothelial activation markers in skin lesions of lacaziosis (Lobomycosis) |
| Year | 2014 |
| PMID | 25450888 |
| Fungal Diseases involved | Jorge Lobo’s disease |
| Associated Medical Condition | None |
| Genus | Lacazia |
| Species | loboi |
| Organism | Lacazia loboi |
| Ethical Statement | The study was approved by the Ethics Committee for the Analysis of Research Projects (Comiss~ ao de Eticavpara Analise de Projetos de Pesquisae CAPPesq) of the Clinical Board of the Uni- versity Hospital, FM USP (Protocol No. 191/12). The study was conducted in accordance with Resolutions 196/96 and 347/05 of the National Health Council regarding the guidelines and standards for research involving humans. |
| Site of Infection | None |
| Opportunistic invasive | None |
| Sample type | Biopsy |
| Sample source | Extracted Tissue |
| Host Group | Human |
| Host Common name | Human |
| Host Scientific name | Homo sapiens |
| Biomarker Name | E-selectin |
| Biomarker Full Name | E-selectin |
| Biomarker Type | Negative |
| Biomolecule | Protein |
| Geographical Location | Brazil |
| Cohort | Paraf n-embedded skin lesion of the lower limbs biopsies from 24 patients with a diagnosis of Jorge Lobo's disease obtained before therapeutic intervention were selected from the archive of the Nucleus of Tropical Medicine, Federal University of Para (Núcleo de Medicina Tropical, Universidade Federal do Para). |
| Cohort No. | 24 |
| Age Group | None |
| P Value | None |
| Sensitivity | None |
| Specificity | None |
| Positive Predictive Value | None |
| MIC | None |
| Fold Change | None |
| Pathway | None |
| Disease Introduction Mechanism | Lobomycosis is a chronic granulomatous infection caused un- cultivable fungus by Lacazia loboi. The disease affects the skin and subcutaneous tissue of humans and members of the family Del- phinidae (dolphins) through inoculation of the fungus, probably associated with trauma |
| Technique | Immunological assay |
| Analysis Method | Immunohistochemistry analysis |
| ELISA kits | None |
| Assay Data | None |
| Validation Techniques used | Immunohistochemistry analysis |
| Up Regulation Down Regulation | Negative |
| Sequence Data | None |
| External Link | None |
