| DB ID | MyCo_3989 |
| Title | M2-Polarized Macrophages Determine Human Cutaneous Lesions in Lacaziosis |
| Year | 2020 |
| PMID | 32378114 |
| Fungal Diseases involved | Lacaziosis |
| Associated Medical Condition | None |
| Genus | Lacazia |
| Species | loboi |
| Organism | Lacazia loboi |
| Ethical Statement | The use of the material that constituted the casuistic was approved by the ethics committee of ClinicalHospital, Faculty of Medicine of University of Sa ˜o Paulo, under the number 191/12. |
| Site of Infection | None |
| Opportunistic invasive | None |
| Sample type | Biopsy |
| Sample source | Extracted tissue |
| Host Group | Human |
| Host Common name | Human |
| Host Scientific name | Homo sapiens |
| Biomarker Name | Arginase-1 |
| Biomarker Full Name | Arginase-1 |
| Biomarker Type | Diagnostic |
| Biomolecule | Protein |
| Geographical Location | Brazil |
| Cohort | Twenty-seven skin biopsies were selected from the files of Nucleo de Medicina Tropical – Universidade Federal do Para, Brazil, from patients with clinical and histological diagnosis of lacaziosis. |
| Cohort No. | 27 |
| Age Group | None |
| P Value | None |
| Sensitivity | None |
| Specificity | None |
| Positive Predictive Value | None |
| MIC | None |
| Fold Change | None |
| Pathway | None |
| Disease Introduction Mechanism | Lacaziosis is a chronic, cutaneous and/or subcuta-neous mycosis, caused by the fungus Lacazia loboi. It mainly affects rural workers since they are in constant contact with the vegetation and soil, characteristic habitat of the fungus. The Amazon region is an important epidemiological site, where there is a high number of patients among the rubber tappers. Lacazia loboi has a rounded form in the host (yeast), a refringent wall and homogeneous or granular cyto- plasm. It is suggested that it occurs in nature in the filamentous form The lesions may present in different aspects: keloidiform, infiltrative, ulcerated or verrucous. They may also be localized, multifocal or disseminated. |
| Technique | Immunological assay |
| Analysis Method | Immunohistochemistry analysis |
| ELISA kits | None |
| Assay Data | None |
| Validation Techniques used | Immunohistochemistry analysis |
| Up Regulation Down Regulation | Increase |
| Sequence Data | None |
| External Link | None |
