| DB ID | MyCo_3970 |
| Title | Skin fibrosis associated with keloid, scleroderma and Jorge Lobo's disease (lacaziosis): An immuno-histochemical study |
| Year | 2022 |
| PMID | 36183172 |
| Fungal Diseases involved | Jorge Lobo’s disease |
| Associated Medical Condition | None |
| Genus | None |
| Species | None |
| Organism | None |
| Ethical Statement | The Institutional Review Board of the Universidade de São Paulo Medical School Hospital approved this study (Protocol #3.534.258). |
| Site of Infection | None |
| Opportunistic invasive | Opportunistic |
| Sample type | Biopsy |
| Sample source | Keloid samples |
| Host Group | Human |
| Host Common name | Human |
| Host Scientific name | Homo sapiens |
| Biomarker Name | TGF- |
| Biomarker Full Name | TGF- |
| Biomarker Type | Diagnostic |
| Biomolecule | Protein |
| Geographical Location | Brazil |
| Cohort | Twenty skin paraffinized skin biopsies samples each of keloids, lacaziosis and scleroderma were retrieved from the archive of the Dermatopathology Laboratory of the Dermatological Clinic Division of Hospital das Clínicas FMUSP. |
| Cohort No. | None |
| Age Group | None |
| P Value | p= .0007 |
| Sensitivity | None |
| Specificity | None |
| Positive Predictive Value | None |
| MIC | None |
| Fold Change | None |
| Pathway | None |
| Disease Introduction Mechanism | Keloid, lacaziosis (Jorge Lobo's disease or lobomycosis) and scleroderma (localized or morphea) are cutaneous diseases with fibroses in their pathogenesis beyond their distinct clinical and histological characterizations. Keloids are caused by injury to the cutaneous reticular dermis in- cluding trauma, insect bite, burn, surgery, vaccination, skin piercing, acne, folliculitis, chicken pox and herpes zoster infection. Lacaziosis is a chronic granulomatous fungal infection of the skin and subcutaneous tissue characterized by keloid-¬ like lesions. |
| Technique | Immunological assay |
| Analysis Method | Immunohistochemistry |
| ELISA kits | None |
| Assay Data | None |
| Validation Techniques used | Immunohistochemistry |
| Up Regulation Down Regulation | Increase |
| Sequence Data | None |
| External Link | None |
