| DB ID | MyCo_3953 |
| Title | Cell proliferation and p53 expression in pseudoepitheliomatous hyperplasia of oral paracoccidioidomycosis |
| Year | 2006 |
| PMID | 16922791 |
| Fungal Diseases involved | Paracoccidioidomycosis |
| Associated Medical Condition | None |
| Genus | Paracoccidioides |
| Species | brasiliensis |
| Organism | Paracoccidioides brasiliensis |
| Ethical Statement | The study protocol was approved by the Ethical Committee in Research of the University of Campinas Dental School. |
| Site of Infection | None |
| Opportunistic invasive | None |
| Sample type | Body fluid |
| Sample source | Blood |
| Host Group | Human |
| Host Common name | Human |
| Host Scientific name | Homo sapiens |
| Biomarker Name | Ki67 |
| Biomarker Full Name | Ki67 |
| Biomarker Type | Diagnostic |
| Biomolecule | Protein |
| Geographical Location | Brazil |
| Cohort | A total of 49 cases, including 18 NOM, 18 oral PCMycosis and 13 cases of oral ED were retrieved from the files of the Department of Oral Pathology, University of Campinas, Dental School. |
| Cohort No. | 49 |
| Age Group | None |
| P Value | None |
| Sensitivity | None |
| Specificity | None |
| Positive Predictive Value | None |
| MIC | None |
| Fold Change | None |
| Pathway | None |
| Disease Introduction Mechanism | Paracoccidioidomycosis (PCMycosis) is a systemic mycosis in Latin America it is caused by the thermally dimorphic fungus, Paracoccidioides brasiliensis (Pb), which is found in soil. The fungus induces the infection by respiratory route and oropharyngeal lesions are secondary to pulmonary infection.1,2 Clinically, the oral lesions classically show an erythaematous finely granular ulceration, speckled with pinpoint haemorrhages, with a mulberry-like surface.1,3 They are usually multiple, affecting gingiva, palate, lip, buccal mucosa, tongue and floor of the mouth. Microscopically, the lesions exhibit epithelioid granulomas, intra-epithelial microabscess and pseudoepitheliomatous hyperplasia (PEH). |
| Technique | Immunological assay |
| Analysis Method | Immunohistochemical -KONTRON 400 image analyser analysis |
| ELISA kits | None |
| Assay Data | None |
| Validation Techniques used | Immunohistochemical -KONTRON 400 image analyser analysis |
| Up Regulation Down Regulation | Positive |
| Sequence Data | None |
| External Link | None |
