| DB ID | MyCo_3909 |
| Title | Serum Aspergillus fumigatus-Specific IgG as a Complementary Biomarker in Differentiating Endotypes of Chronic Rhinosinusitis: A Study on Its Role and Diagnostic Efficacy in Type 2 Inflammation |
| Year | 2024 |
| PMID | 38751051 |
| Fungal Diseases involved | Allergic bronchopulmonary aspergillosis |
| Associated Medical Condition | None |
| Genus | Aspergillus |
| Species | fumigatus |
| Organism | Aspergillus fumigatus |
| Ethical Statement | This study was approved by the Institutional Review Board of Chang Gung Memorial Hospital (201902084B0) and all patients were provided written informed consent before enrollment. |
| Site of Infection | None |
| Opportunistic invasive | None |
| Sample type | Body fluid |
| Sample source | Serum |
| Host Group | Human |
| Host Common name | Human |
| Host Scientific name | Homo sapiens |
| Biomarker Name | Af-sIgG |
| Biomarker Full Name | Aspergillus fumigatus-speci c immunoglobulin G |
| Biomarker Type | Diagnostic |
| Biomolecule | Protein |
| Geographical Location | Taiwan |
| Cohort | Initially, 75 patients with bilateral CRS were enrolled, of which, 24 patients with secondary CRS and one with AFRS were excluded. Eventually, 50 patients were enrolled, including 26 patients who met the de nition of T2 CRS and 24 patients categorized as the non-T2 group. |
| Cohort No. | 50 |
| Age Group | 29-59 |
| P Value | None |
| Sensitivity | None |
| Specificity | None |
| Positive Predictive Value | None |
| MIC | None |
| Fold Change | None |
| Pathway | None |
| Disease Introduction Mechanism | None |
| Technique | Immunological assay |
| Analysis Method | ImmunoCAP Analysis |
| ELISA kits | ImmunoCAP system Kit (Phadia, Thermo Fisher Scienti c, MA). |
| Assay Data | None |
| Validation Techniques used | ImmunoCAP Analysis |
| Up Regulation Down Regulation | Positive |
| Sequence Data | None |
| External Link | None |
