| DB ID | MyCo_3908 |
| Title | High level of initial Aspergillus fumigatus-specific IgE links increased risk of exacerbation in allergic bronchopulmonary aspergillosis patients |
| Year | 2025 |
| PMID | 40065361 |
| Fungal Diseases involved | Allergic bronchopulmonary aspergillosis |
| Associated Medical Condition | None |
| Genus | Aspergillus |
| Species | fumigatus |
| Organism | Aspergillus fumigatus |
| Ethical Statement | Ethical approval was obtained from the Ethics Commit- tees of Shanghai Pulmonary Hospital, Tongji University (No. K18-153 and K18-167) and Zhongshan Hospital, Fudan University (No. B2019-020R and B2021-353). |
| Site of Infection | None |
| Opportunistic invasive | None |
| Sample type | Body fluid |
| Sample source | Serum |
| Host Group | Human |
| Host Common name | Human |
| Host Scientific name | Homo sapiens |
| Biomarker Name | Aspergillus fumigatus-specific IgE (> 9.88 kUA/L) |
| Biomarker Full Name | Aspergillus fumigatus-specific Immunoglobulin E (> 9.88 kUA/L) |
| Biomarker Type | Prognostic |
| Biomolecule | Protein |
| Geographical Location | China |
| Cohort | This study enrolled 149 acute ABPA patients. |
| Cohort No. | 149 |
| Age Group | 71 |
| P Value | p=0.005 |
| Sensitivity | None |
| Specificity | None |
| Positive Predictive Value | None |
| MIC | None |
| Fold Change | None |
| Pathway | None |
| Disease Introduction Mechanism | Allergic bronchopulmonary aspergillosis (ABPA) is a complex allergic disease caused by Aspergillus fumigatus (A. fumigatus), first systematically described in 1952. The chronic colonization of A. fumigatus in the airway and enhanced type 2 immune response are key patho-genic mechanisms of ABPA. According to a global epidemiological survey conducted in 2023, the preva- lence of ABPA is as high as 11.3% in adults with asthma and 9.9% in children with asthma. Given the pos-sibility of underdiagnosis and misdiagnosis, the actual prevalence of ABPA may be underreported. |
| Technique | Immunological assay |
| Analysis Method | ImmunoCAP 1000 Assay |
| ELISA kits | ImmunoCAP 1000 system Kit (Phadia, Thermo Fisher Scienti c, MA). |
| Assay Data | None |
| Validation Techniques used | ImmunoCAP 1000 Assay |
| Up Regulation Down Regulation | Increase |
| Sequence Data | None |
| External Link | None |
