| DB ID | MyCo_3901 |
| Title | Phosphoinositide 3-kinase-δ regulates fungus-induced allergic lung inflammation through endoplasmic reticulum stress |
| Year | 2015 |
| PMID | 26543090 |
| Fungal Diseases involved | Allergic bronchopulmonary aspergillosis |
| Associated Medical Condition | Lung inflammation |
| Genus | Aspergillus |
| Species | fumigatus |
| Organism | Aspergillus fumigatus |
| Ethical Statement | All experimental animals used in this study were under a protocol approved by the Institutional Animal Care and Use Committee of the Chonbuk National University (CBU 2014-00030). |
| Site of Infection | Lungs |
| Opportunistic invasive | None |
| Sample type | Biopsy |
| Sample source | Extracted Lungs tissue |
| Host Group | Animal |
| Host Common name | Mice |
| Host Scientific name | Mus musculus |
| Biomarker Name | GRP78 |
| Biomarker Full Name | GRP78 |
| Biomarker Type | Diagnostic |
| Biomolecule | Protein |
| Geographical Location | South Korea |
| Cohort | Female C57BL/6 mice, 8–10 weeks of age and free of murine specific pathogens, were used. |
| Cohort No. | None |
| Age Group | None |
| P Value | None |
| Sensitivity | None |
| Specificity | None |
| Positive Predictive Value | None |
| MIC | None |
| Fold Change | None |
| Pathway | None |
| Disease Introduction Mechanism | Aspergillus fumigatus (Af) is ubiquitous in normal air and the human respiratory system is constantly exposed to airborne spores of Af. Various lung dis- orders including invasive aspergillosis, aspergilloma, bronchial asthma and allergic bronchopulmonary aspergillosis (ABPA) are commonly associated with Af. Among them, ABPA and bronchial asthma are representative allergic lung inflammatory disorders related to Af. ABPA is one of the complex hypersensitivity reactions to Aspergillus species usually colonised in bronchi and it occurs in patients with asthma. Although many patients with ABPA respond well to treatment with systemic ster-oids, the condition of some patients is poorly con- trolled by conventional management. Additionally, in patients with bronchial asthma, sensitisation with Af is known to cause severe phenotypes of the disease. However, the mechanisms by which Af is involved in allergic lung inflammation remain poorly understood. |
| Technique | Immunological assay |
| Analysis Method | Immuno uorescence staining |
| ELISA kits | None |
| Assay Data | None |
| Validation Techniques used | PIP3 competition enzyme immunoassay, Western blot analysis, Immuno uorescence staining |
| Up Regulation Down Regulation | Increase |
| Sequence Data | None |
| External Link | None |
