| DB ID | MyCo_3893 |
| Title | Variable number of tandem repeats of TNF receptor type 2 promoter as genetic biomarker of susceptibility to develop invasive pulmonary aspergillosis |
| Year | 2007 |
| PMID | 17207711 |
| Fungal Diseases involved | Invasive pulmonary aspergillosis |
| Associated Medical Condition | None |
| Genus | Aspergillus |
| Species | fumigatus |
| Organism | Aspergillus fumigatus |
| Ethical Statement | Written informed consent for this genome research was obtained from all participants and the study was approved by the ethical review committee of our institution, Hospital Universitario Virgen de las Nieves, Granada, Spain. |
| Site of Infection | None |
| Opportunistic invasive | Invasive |
| Sample type | Body fluid |
| Sample source | Plasma |
| Host Group | Human |
| Host Common name | Human |
| Host Scientific name | Homo sapiens |
| Biomarker Name | TNFα |
| Biomarker Full Name | Tumour necrosis factor alpha |
| Biomarker Type | Negative |
| Biomolecule | Protein |
| Geographical Location | Spain |
| Cohort | A prospective study was undertaken to investigate whether genetic variations in TNF- and LT- and their receptors are associated with susceptibility to develop IPA. All patients with hematologic malignancies treated with prolonged chemotherapy (therefore considered sus- ceptible to develop IPA) at our Department of Hema- tology from January 2004 to August 2006, 102 patients, and 124 age-matched controls were included in this study. |
| Cohort No. | 102 Patients and 124 control |
| Age Group | None |
| P Value | None |
| Sensitivity | None |
| Specificity | None |
| Positive Predictive Value | None |
| MIC | None |
| Fold Change | None |
| Pathway | None |
| Disease Introduction Mechanism | None |
| Technique | Analytic |
| Analysis Method | Human Th1/Th2 cytokine cytometric bead array analysis |
| ELISA kits | human Th1/Th2 cytokine cytometric bead array kit (BD Biosciences, San Diego, CA) |
| Assay Data | None |
| Validation Techniques used | Human Th1/Th2 cytokine cytometric bead array analysis |
| Up Regulation Down Regulation | Negative |
| Sequence Data | None |
| External Link | None |
