| DB ID | MyCo_3823 |
| Title | Pulsed echinocandin therapy in azole intolerant or multiresistant chronic pulmonary aspergillosis: A retrospective review at a UK tertiary centre |
| Year | 2020 |
| PMID | 32077238 |
| Fungal Diseases involved | Chronic pulmonary aspergillosis |
| Associated Medical Condition | None |
| Genus | Aspergillus |
| Species | fumigatus |
| Organism | Aspergillus fumigatus |
| Ethical Statement | This study was reviewed by our local trust research board and as a retrospective, non-interventional project, was deemed service evaluation and hence did not require formal ethical approval. |
| Site of Infection | None |
| Opportunistic invasive | None |
| Sample type | None |
| Sample source | None |
| Host Group | Human |
| Host Common name | Human |
| Host Scientific name | Homo sapiens |
| Biomarker Name | FEV1 |
| Biomarker Full Name | forced expiratory volume after 1 minute |
| Biomarker Type | Prognostic |
| Biomolecule | None |
| Geographical Location | UK |
| Cohort | Electronic Patient Records at the Royal Brompton Hospital, a single tertiary referral centre, were interrogated for CPA patients treated with intravenous caspofungin between 2008 and 2012. A total of 25 patients were identified, of whom six had either pan-azole resistance (itraconazole, voriconazole and posaconazole) or were azole intolerant. |
| Cohort No. | 25 |
| Age Group | 39-66 |
| P Value | None |
| Sensitivity | None |
| Specificity | None |
| Positive Predictive Value | None |
| MIC | None |
| Fold Change | None |
| Pathway | None |
| Disease Introduction Mechanism | Chronic pulmonary aspergillosis (CPA) lies at the severe 1 end of a spectrum of diseases caused by Aspergillus spp. Aspergillus spp. are saprophytic fungi commonly found in soil and decaying organic material, and are thus fairly ubiq- uitous to most environments. Depending on the host immune response, inhalation can lead to a range of pulmonary disease manifestations, from allergic sensitization and allergic bron- chopulmonary aspergillosis to acute invasive aspergillosis and CPA. Most pulmonary aspergillus disease is attributed to Aspergillus fumigatus, but Aspergillus flavus and Aspergillus niger may also be implicated. |
| Technique | CT scan |
| Analysis Method | HRCT scans |
| ELISA kits | ImmunoCAP fluoro-enyme immunoassay Kit (Phadia AB, Uppsalla, Sweden). |
| Assay Data | None |
| Validation Techniques used | HRCT scans |
| Up Regulation Down Regulation | Increase |
| Sequence Data | None |
| External Link | None |
